Immunology Research Scientist

2 weeks ago

San Carlos, California, United States MBC BioLabs Full time

Position Overview
MBC BioLabs is on the lookout for a dedicated and driven scientist with expertise in immunology or cell biology, acquired through academic or industry experience. The ideal candidate will possess a robust understanding of T cell biology and will spearhead the design, execution, and analysis of both in vitro and in vivo assays aimed at evaluating the anti-tumor efficacy of innovative compounds such as next-generation T cell engagers or CAR-T cells, utilizing MBC BioLabs' proprietary technologies.

Key Responsibilities

  1. Conduct cell biology tasks, including the isolation, characterization, and assay development with primary human and murine immune cells, as well as tumor cell lines pertinent to immuno-oncology research.
  2. Design and implement experiments focused on immune cell profiling, cytotoxicity, proliferation, activation, and survival assays, with a significant emphasis on flow cytometry to assess the functionality of bispecific antibody compounds or CAR-T cells.
  3. Oversee the application of these assays in compound screening, optimization, and characterization.
  4. Generate necessary reagents for projects, including the preparation of lentivirus for transducing established cell lines and primary immune cells.
  5. Manage the selection, study design, project oversight, and data analysis for animal models to evaluate anti-tumor effects in collaboration with external partners.
  6. Conduct immunological analyses related to cellular and animal models.
  7. Perform gene editing on primary human immune cells using advanced technologies such as CRISPR and TALEN, along with molecular biology experiments like DNA and protein preparation, immunoprecipitation, and western blotting.

Team Collaboration

  • Work closely with the market segment/application lead to devise experimental strategies.
  • Interpret, document, and present data from in vitro and in vivo models, drawing logical conclusions and communicating findings to project teams.
  • Execute biochemical analyses to evaluate the functions of compounds and CAR-T cells in cell-based assays.
  • Independently identify and implement solutions based on published research.
  • Prepare reports and present results during regular team meetings.
  • Support the team with immunological inquiries.
  • Foster effective communication and collaboration with colleagues.
  • Manage multiple tasks and priorities to ensure successful project outcomes.

Qualifications

  • Ph.D. with up to 2 years of research experience in cell or tumor immunology, cell biology, or related fields, or a Master's/Bachelor's degree with a minimum of 5 years of relevant experience and a proven track record of accomplishments and publications.
  • Technical proficiency in a variety of tumor immunology techniques, including cell culture, flow cytometry, microscopy, xenograft models, and bioinformatics tools.
  • Hands-on experience in mammalian cell culture, tumor cell assays, and cytokine quantification.
  • Exceptional communication skills with the ability to work independently and collaboratively.
  • Strong critical thinking abilities with a high level of innovative and analytical skills.
  • Self-motivated to contribute to the development of next-generation immunotherapies.

Preferred Qualifications

  • Experience in the industry focused on immunology or tumor research.
  • Able to thrive in a dynamic startup environment.
  • Familiarity with bispecific antibody and CAR-T cell experiments.
  • Knowledge of tumor models in mice and mouse immunology.
  • Experience with T/B/NK/macrophage cell biology.
  • Proficiency in gene editing, cell transfection, and transduction systems.
  • Experience in preparing reagents for in vivo assays and conducting in vivo experiments.
  • Background in protein engineering and antibody design.
  • Familiarity with biological and statistical software such as Prism, FlowJo, or JMP.

What We Provide

  • Opportunities for rapid career advancement unique to a small startup.
  • Flexible working hours.
  • A highly motivated and enthusiastic team.
  • An attractive compensation package.

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