Research Scientist
1 week ago
Job Summary:
System One is seeking a highly motivated Research Scientist to join our team in San Diego, CA. As a Research Scientist, you will be responsible for designing and conducting essential mechanistic experiments in cell biology, cellular biochemistry, molecular biology, and assay development.
Key Responsibilities:
- Design and Conduct Experiments: Utilize and develop multiple disease models to design target validation studies and relevant assays in support of SAR, mechanism of action, mechanisms of resistance, biomarker selection, and disease positioning.
- Cell-Based Assay Development: Develop and implement cell-based assays to address both tumor intrinsic cellular biology and immune-based mechanisms of action for potential drug candidates.
- Experimentation and Data Analysis: Design and conduct essential mechanistic experiments in cell biology, cellular biochemistry, molecular biology, and assay development, and accurately maintain written reports and present results in an organized and timely manner.
- Team Collaboration: Communicate effectively, foster teamwork, and contribute to collaborative efforts.
- Quality and Adaptability: Strong commitment to quality and demonstrate adaptability.
Requirements:
- Education: Ph.D. in cell biology, immunology, molecular biology, or equivalent field with 0-2 years of post-doc or industry experience, or M.S. degree with 3+ years of experience, or Bachelor's degree with 5+ years of experience in the biopharmaceutical industry developing and optimizing cell-based assays, preferably in Oncology.
- Experience: Strong background and experience in cancer research with training in molecular and cell biology.
- Technical Skills: Extensive experience using multi-parameter flow cytometry in the context of primary immune cell isolation and characterization is required. Extensive hands-on experience with mammalian cell culture, molecular and cellular technologies (e.g., CRISPR/Cas9 knock-in/out, lentiviral transduction, western blotting, quantitative PCR,) and functional assays (e.g., proliferation, apoptosis, cell cycle) is essential.
- Software Proficiency: Proficiency in scientific data analysis programs including GraphPad Prism, FlowJo, Microsoft Excel/Powerpoint, is required.
- Communication Skills: Ability to deliver high-quality data in an organized and timely manner, and ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude and independently collaborate across teams, requiring excellent communication skills, both written and verbal, with strong interpersonal skills.
Benefits:
System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
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