Immunology Research Scientist
2 weeks ago
Position Overview
MBC BioLabs is on the lookout for a passionate and driven scientist specializing in immunology or cell biology, with experience from either academic or commercial environments. The ideal candidate will possess a robust understanding of T cell biology and will spearhead the design, execution, and analysis of both in vitro and in vivo assays aimed at evaluating the anti-tumor efficacy of innovative compounds such as next-generation T cell engagers or CAR-T cells, utilizing MBC BioLabs' proprietary technology.
Key Responsibilities
- Conduct cell biology tasks, including the isolation, characterization, and setup of assays involving primary human and murine immune cells, tumor cell lines relevant to immuno-oncology, and primary patient-derived cells.
- Design and perform experiments focused on immune cell profiling, cell processing from xenograft models, and various assays including cytotoxicity, proliferation, activation, and cell viability, with a significant emphasis on flow cytometry to evaluate the functionality of bispecific antibody compounds or CAR-T cells.
- Implement these assays for compound screening, optimization, and characterization purposes.
- Generate necessary reagents for projects, including the preparation of lentivirus for transduction of established cell lines and primary immune cells.
- Oversee study design, project management, and data analysis for animal models assessing anti-tumor effects, collaborating with external partners.
- Conduct immunological analyses pertinent to cellular and animal models.
- Utilize advanced gene editing techniques on primary human immune cells, employing cutting-edge technologies such as CRISPR and TALEN, alongside other molecular biology methodologies including DNA and protein preparation, immunoprecipitation, and western blotting.
Team Collaboration
- Work closely with market segment/application leads to strategize experimental approaches.
- Interpret, document, and present data from in vitro and in vivo models, drawing logical conclusions and communicating findings to project teams.
- Conduct biochemical analyses to evaluate the functions of compounds and CAR-T cells in cell-based assays, including cell killing assays and flow cytometry.
- Independently identify and implement solutions based on published research.
- Prepare reports and present findings during regular team meetings.
- Support the team with all immunological inquiries.
- Foster effective communication and collaboration with colleagues.
- Manage multiple tasks and priorities to ensure successful project outcomes.
Qualifications
- Ph.D. with up to 2 years of research experience in cell or tumor immunology, cell biology, or related disciplines, or a Master's/Bachelor's degree with a minimum of 5 years of relevant experience and a proven track record of achievements and publications.
- Technical proficiency in a broad array of tumor immunology techniques, including cell culture, flow cytometry, microscopy, xenograft models, and bioinformatics tools.
- Hands-on experience in mammalian cell culture, tumor cell assays, and cytokine quantification.
- Exceptional communication skills, with the ability to work both independently and collaboratively.
- Strong critical thinking abilities coupled with innovative and analytical skills.
- Self-motivated to contribute to the development of cutting-edge immunotherapies.
Preferred Qualifications
- Experience in the industry related to immunology or tumor research.
- Aptitude for thriving in a dynamic startup environment.
- Familiarity with bispecific antibody and CAR-T cell experiments.
- Knowledge of tumor models in mice and mouse immunology.
- Experience with T/B/NK/macrophage cell biology.
- Proficiency in gene editing, cell transfection, and transduction systems.
- Experience in preparing reagents for in vivo assays and conducting in vivo experiments.
- Background in protein engineering and antibody design.
- Familiarity with biological and statistical software such as Prism, FlowJo, or JMP is advantageous.
What We Provide
- Opportunities for rapid career advancement unique to a small startup.
- Flexible working hours.
- A highly motivated and enthusiastic team.
- An attractive compensation package.
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