Senior Scientist in LNP Formulation

2 weeks ago

Lexington, Kentucky, United States Mote Therapeutics Inc. Full time
Position Overview

Company Overview:
Mote Therapeutics Inc. is at the forefront of pioneering RNA therapeutics, dedicated to transforming the landscape of medicine. Our innovative team is committed to addressing the challenges in RNA delivery systems, and we are looking for a talented individual to join our efforts.

Role Summary:
We are in search of a scientific expert to spearhead the discovery of novel lipid nanoparticle (LNP) formulations aimed at enhancing the delivery of circular RNA therapeutic molecules. The selected candidate will play a crucial role in designing and evaluating formulations in preclinical models. Responsibilities will include engineering and optimizing LNPs, developing analytical methods for quality assurance, and refining processes for large-scale production.

Key Responsibilities:

  • Evaluate innovative formulations and materials for the efficacy of circular RNA delivery across various biological environments, particularly in vivo.
  • Assist in the enhancement of formulation and analytical capabilities focusing on nanoparticle technology, lyophilization, and process development for scalability.
  • Contribute to intellectual property initiatives related to delivery technologies.
  • Build and maintain collaborative relationships within the team and the broader organization, fostering a positive and engaging work atmosphere.
  • Recruit, mentor, and oversee scientists as necessary to develop, characterize, and assess the efficacy of formulations.
  • Plan and coordinate preclinical studies in collaboration with the in vivo research team.
  • Draft technical documentation, including Standard Operating Procedures for formulation processes and analytical methodologies.

Qualifications:

Minimum Requirements:

  • MS/Ph.D. in chemical engineering, chemistry, pharmaceutical sciences, or a related discipline, with relevant industry experience of 4-5 years for MS or 1-2 years for PhD.
  • Proven track record in nanoparticle research, with a solid understanding of the challenges associated with nanoparticle formulation and scale-up.
  • Experience in developing lyophilization protocols for nanoparticle formulations and conducting stability assessments is advantageous.
  • Technical expertise in LNP formulation for RNA and analytical techniques for particle characterization.
  • A minimum of 2-3 years of experience working with lipid nanoparticles for RNA delivery in any capacity.

Preferred Qualifications:

  • Demonstrated proficiency in LNP formulation for nucleic acid delivery is highly desirable.
  • Experience in LNP process development and scale-up is preferred.
  • Familiarity with tissue-specific targeted delivery of LNP-nucleic acid formulations is a plus.
  • Ability to effectively communicate complex technical concepts to diverse audiences.
  • Prior experience in training and developing scientists is beneficial.

Why Mote Therapeutics Inc.?
We offer a competitive compensation package along with comprehensive health and wellness programs. Our commitment to employee growth and development is reflected in our supportive work environment and opportunities for professional advancement.

Core Values:
We believe in thinking bigger, embracing innovation, displaying courage, evolving continuously, and simplifying processes to achieve our goals.

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