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Senior Scientist in LNP Formulation
2 months ago
Company Overview:
Mote Therapeutics Inc. is a pioneering biotechnology firm focused on revolutionizing RNA therapeutics. We are dedicated to creating innovative solutions that address significant challenges in the field of RNA medicine.
Role Summary:
We are looking for a scientific expert to spearhead the discovery of novel lipid nanoparticle (LNP) formulations aimed at delivering circular RNA therapeutic agents. The successful candidate will be tasked with designing and evaluating formulations in preclinical models. This role involves engineering and optimizing LNPs, developing analytical methods for quality assurance, and creating scalable processes for formulation production.
Key Responsibilities:
- Evaluate innovative formulations and materials for the effective delivery of circular RNA in various biological settings, particularly in vivo.
- Assist in enhancing formulation and analytical capabilities, focusing on nanoparticle technology, lyophilization, and process development for scalability.
- Contribute to intellectual property applications concerning delivery technologies.
- Foster collaborative relationships within the team and across the organization, promoting a positive and engaging work atmosphere.
- Recruit, mentor, and manage scientists to formulate, characterize, and assess the efficacy of new LNP formulations.
- Plan and oversee animal studies in collaboration with the in vivo research team.
- Prepare technical documentation, including Standard Operating Procedures for formulation processes and analytical techniques.
Qualifications:
Minimum Requirements:
- MS/Ph.D. in chemical engineering, chemistry, pharmaceutical sciences, or a related discipline, with relevant industry experience (4-5 years for MS or 1-2 years for PhD).
- Proven track record in nanoparticle research, with an understanding of the challenges associated with nanoparticle formulation and scale-up.
- Experience in developing lyophilization protocols for nanoparticle formulations and conducting stability assessments is advantageous.
- Technical expertise in LNP formulation for RNA and analytical methods for particle characterization.
- A minimum of 2-3 years of experience working with lipid nanoparticles for RNA delivery.
Preferred Qualifications:
- Demonstrated proficiency in LNP formulation for nucleic acid delivery.
- Experience in LNP process development and scale-up is highly desirable.
- Familiarity with tissue-specific targeted delivery of LNP-nucleic acid formulations is a plus.
- Ability to communicate complex technical topics to diverse audiences.
- Prior experience in training and developing scientists.
Additional Information:
Mote Therapeutics Inc. offers a comprehensive benefits package designed to support the well-being of our employees, including competitive compensation, health care benefits, generous paid time off, and a supportive work environment that encourages professional growth.
Core Values:
We are committed to fostering a culture that values innovation, collaboration, and continuous improvement.