Scientist I/II, Integrative Biology

4 weeks ago


Cambridge, Massachusetts, United States Sail Biomedicines Full time


About Sail:



Sail Biomedicines is harnessing evolutionary and artificial intelligence to revolutionize programmable medicines. Sail's platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is building a wealth of data, enabling unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.



The Role:

We are searching for an innovative and highly motivated Scientist I/II to join the Integrative Biology group at Sail Biomedicines. Collaborating with an interdisciplinary team experienced in molecular biology, bioengineering, pharmacology, data science, and machine learning, this individual will develop and scale robust assays to discover the next generation of RNA medicines. The ideal candidate will bring a track record of scientific initiative and a deep commitment to teamwork to the Integrative Biology group's fast-paced culture of scientific rigor.

Responsibilities:

Help us build Sail's core technological platform and discover novel therapeutics. Operate outside your scientific comfort zone to lead and support multiple projects from ideation through execution. Develop methods to assay the properties and performance of novel RNAs and Nanoparticles. Collaborate with automation scientists to scale assays for high throughput. Maintain impeccable documentation within Sail's digital lab environment. Support the integration of machine learning into our science.

Necessary Qualifications:

PhD in Nanotechnology, bioengineering or a closely related field or M.Sc. with 2+ years of experience working in either industry or academic research. (or equivalent combination of education and experience) Strong background in experimental design, data analysis, and interpretation. Effective communication with both technical and non-technical audiences. Proficiency developing assays from scratch and utilizing commercial bioassays. Ability to work effectively with minimal direction and oversight.

Desired Qualifications:

Experience with lipid nanoparticles (e.g., particle formulation, chemical and biophysical characterization, and bio-molecule interactions). Experience developing high-throughput biochemical (e.g., Immunoprecipitation), molecular (e.g., qPCR), or cell-based assays (e.g., microscopy).Automation experience (e.g. liquid handlers).

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.




  • Cambridge, Massachusetts, United States Sail Biomedicines Full time

    About Sail:Sail Biomedicines is harnessing evolutionary and artificial intelligence to revolutionize programmable medicines. Sail's platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines...


  • Cambridge, Massachusetts, United States Repertoire Immune Medicines Full time

    Job OverviewPosition: Research Associate I/IIFocus Area: Automation & Next-Generation Sequencing (NGS)Company Background:Repertoire Immune Medicines is a pioneering biotechnology firm dedicated to harnessing the extraordinary capabilities of the human immune system to combat cancer, autoimmune disorders, and infectious diseases. Founded by Flagship...


  • Cambridge, Massachusetts, United States GC Therapeutics Full time

    Position: Scientist / Senior Scientist – Computational BiologyCompany OverviewGC Therapeutics is a pioneering company focused on genome-wide cell landscape exploration, utilizing an integrated synthetic biology and AI-driven platform for cell programming. Our proprietary technology platform, TFomeTM, developed in the lab of Professor George Church, a...


  • Cambridge, Massachusetts, United States Flare Therapeutics Full time

    Flare Therapeutics is a biotechnology company pioneering a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare's team has uncovered 'switch sites,' druggable regions that are key targets for transcription...

  • Biology Scientist

    1 week ago


    Cambridge, Massachusetts, United States Third Rock Ventures Full time

    In Vivo Pharmacology ScientistA dynamic and well-supported startup, backed by Third Rock Ventures, is transitioning from stealth mode and is on the lookout for a skilled Scientist to enhance the Biology-In Vivo Pharmacology team. This role will be pivotal as the in vivo pharmacology expert for discovery-stage pipeline initiatives targeting antibody-related...


  • Cambridge, Massachusetts, United States Pioneer Data Systems Full time

    At Pioneer Data Systems, we are seeking a dedicated Research Scientist II to enhance our dynamic team. We encourage you to review the qualifications and experience required for this role outlined below.Position Overview:Job Title: Research Scientist II (Advanced Flow Cytometry, Cellular Studies) Duration: 12 months contract, with potential for extension up...


  • Cambridge, Massachusetts, United States Repertoire Immune Medicines Full time

    Job OverviewPosition: Research Associate I/IIFocus: Automation & Next-Generation Sequencing (NGS)Company BackgroundRepertoire Immune Medicines is a pioneering biotechnology firm dedicated to harnessing the extraordinary capabilities of the human immune system for the treatment of cancer, autoimmune disorders, and infectious diseases. Founded by Flagship...


  • Cambridge, Massachusetts, United States Repertoire Immune Medicines Full time

    Job OverviewPosition: Research Associate I/IIField: Automation & Next-Generation Sequencing (NGS)Company BackgroundRepertoire Immune Medicines is a pioneering biotechnology firm dedicated to harnessing the extraordinary capabilities of the human immune system to combat cancer, autoimmune disorders, and infectious diseases. Founded by Flagship Pioneering, the...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Position OverviewLocation: Onsite. Internal Title: Principal Scientist I/II About the Role: The Oncology Translational Research (OTR) team at Novartis is in search of a driven professional to take on the role of lab head, focusing on the exploration of mechanisms behind the effectiveness and resistance to innovative cancer treatments. Collaborating closely...

  • Research Scientist

    5 days ago


    Cambridge, Massachusetts, United States Sunrise Systems Inc Full time

    **Job Summary**Sunrise Systems Inc is seeking a highly motivated Associate Research Scientist to support our Discovery Biology research programs at our facility. The ideal candidate will contribute to our discovery pipeline from the bench by taking responsibility for developing, optimizing, and troubleshooting cellular assays to characterize and advance our...

  • Research Scientist

    6 days ago


    Cambridge, Massachusetts, United States Sunrise Systems Inc Full time

    **Job Summary**Sunrise Systems Inc is seeking a highly motivated Associate Research Scientist to support our Discovery Biology research programs at our facility. The ideal candidate will contribute to our discovery pipeline from the bench by taking responsibility for developing, optimizing, and troubleshooting cellular assays to characterize and advance our...


  • Cambridge, Massachusetts, United States Synectics Inc Full time

    Job OverviewPosition Summary: This role is pivotal in leveraging molecular biology knowledge to foster advancements in the engineering and development of cutting-edge RNA therapeutics, including circRNA and saRNA. Collaborate within a vibrant team of forward-thinking scientists to enhance RNA design, stability, and translation efficiency. Investigate and...


  • Cambridge, Massachusetts, United States Flagship Ventures Full time

    Join a Pioneering OrganizationImagine being part of a company that not only creates but also resources and develops life sciences ventures that innovate groundbreaking technologies aimed at transforming healthcare.The ChallengeIn the current healthcare landscape, diagnosing diseases frequently involves invasive methods, such as biopsies, which allow for...


  • Cambridge, Massachusetts, United States Flagship Ventures Full time

    Position Overview:We are in search of a dynamic and driven scientist with substantial expertise in computational structural biology, coupled with outstanding AI/ML computational and programming capabilities. This role is pivotal in providing strategic vision, innovative thinking, and critical insights for the advancement of novel protein-based therapies at...


  • Cambridge, Massachusetts, United States GC Therapeutics Full time

    In Vivo Research ScientistCompany OverviewGC Therapeutics is pioneering the exploration of genome-wide cell landscapes through an innovative synthetic biology and AI-driven platform for cell programming. Our proprietary pluripotent stem cell differentiation technology, TFomeTM, was developed in collaboration with Professor George Church's lab, a leader in...


  • Cambridge, Massachusetts, United States GlaxoSmithKline Full time

    Site Name: Cambridge Binney StreetPosted Date: Aug 1 2024Job Title: Scientist, Preclinical Molecular Biology - MAPS Vaccine PlatformCompany: GSK (GlaxoSmithKline)Location: Binney Street, Cambridge, MAJob Type: Full-timeAt GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is...


  • Cambridge, Massachusetts, United States American Society of Plant Biologists Full time

    About the RoleWe are seeking a highly skilled Senior Research Scientist, Plant Molecular Biology Specialist to join our team at the American Society of Plant Biologists. As a key member of our research team, you will be responsible for leading the development of our plant cell culture platform and driving innovation in plant molecular biology.Key...


  • Cambridge, Massachusetts, United States Novartis Farmacéutica Full time

    Position OverviewThe Oncology Translational Research (OTR) team at Novartis is in search of a dedicated and skilled individual to take on the role of lab head, focusing on the exploration of mechanisms behind the effectiveness and resistance to innovative cancer treatments.Key ResponsibilitiesUtilize preclinical methodologies and clinical samples to...


  • Cambridge, Massachusetts, United States Merck Full time

    Job DescriptionOur company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us. Our ability to excel depends on the...


  • Cambridge, Massachusetts, United States Broad Institute Full time

    Overview of the Infectious Disease and Microbiome Program (IDMP):The Infectious Disease and Microbiome Program (IDMP) is on the lookout for an experienced Group Leader in Computational Biology to spearhead research projects that investigate the interactions between hosts and microbiomes across various health scenarios. The selected individual will be an...