Biology Scientist

2 weeks ago


Cambridge, Massachusetts, United States Third Rock Ventures Full time

In Vivo Pharmacology Scientist

A dynamic and well-supported startup, backed by Third Rock Ventures, is transitioning from stealth mode and is on the lookout for a skilled Scientist to enhance the Biology-In Vivo Pharmacology team. This role will be pivotal as the in vivo pharmacology expert for discovery-stage pipeline initiatives targeting antibody-related diseases. The Scientist will collaborate closely with the Biology team leaders to assist in lead characterization and the selection of development candidates. Additionally, the Scientist will play a crucial role in establishing and overseeing internal in vivo pharmacology capabilities.

Key Responsibilities:

  • Support the establishment and management of internal in vivo pharmacology capabilities within a shared vivarium, including animal handling.
  • Act as the functional team leader for preclinical pipeline initiatives, partnering with peer team leaders to progress programs toward IND submission.
  • Design and oversee in vivo biological experiments that facilitate preclinical drug discovery, including pharmacokinetic/pharmacodynamic (PK/PD) analysis, mechanism of action investigations, and disease modeling.
  • Independently create and implement quantitative assays for the evaluation and characterization of ex vivo samples (e.g., ELISA, flow cytometry).
  • Manage certain outsourced workflows from contract research organizations (CROs).

Required Qualifications and Experience:

  • Ph.D. in a relevant scientific discipline, such as immunology or cell/molecular biology, with 0-3 years of experience in the biotech or pharmaceutical industry, or a BA/BS in a relevant scientific field with over 8 years of experience focusing on in vivo pharmacology.
  • Comprehensive experience in designing and executing in vivo studies, including ex vivo analysis.
  • Able to thrive in a dynamic matrix environment, contributing significantly to project strategy and execution.
  • Strong communication, presentation, and interpersonal skills; exceptional organizational and problem-solving abilities.
  • Experience in designing toxicology studies is preferred.
  • Contributions to the design and execution of IND-enabling in vivo studies are preferred.


  • Cambridge, Massachusetts, United States GC Therapeutics Full time

    Position: Scientist / Senior Scientist – Computational BiologyCompany OverviewGC Therapeutics is a pioneering company focused on genome-wide cell landscape exploration, utilizing an integrated synthetic biology and AI-driven platform for cell programming. Our proprietary technology platform, TFomeTM, developed in the lab of Professor George Church, a...

  • Research Scientist

    7 days ago


    Cambridge, Massachusetts, United States Sunrise Systems Inc Full time

    **Job Summary**Sunrise Systems Inc is seeking a highly motivated Associate Research Scientist to support our Discovery Biology research programs at our facility. The ideal candidate will contribute to our discovery pipeline from the bench by taking responsibility for developing, optimizing, and troubleshooting cellular assays to characterize and advance our...

  • Research Scientist

    1 week ago


    Cambridge, Massachusetts, United States Sunrise Systems Inc Full time

    **Job Summary**Sunrise Systems Inc is seeking a highly motivated Associate Research Scientist to support our Discovery Biology research programs at our facility. The ideal candidate will contribute to our discovery pipeline from the bench by taking responsibility for developing, optimizing, and troubleshooting cellular assays to characterize and advance our...


  • Cambridge, Massachusetts, United States GC Therapeutics Full time

    About GC TherapeuticsGC Therapeutics is a pioneering genome-wide cell landscape exploration company that leverages an integrated synthetic biology and AI-driven platform for cell programming. Our patent-pending and proprietary pluripotent stem cell differentiation technology platform, TFomeTM, was developed in collaboration with Professor George Church's...


  • Cambridge, Massachusetts, United States Atlas Venture Full time

    About the RoleWe are seeking a highly motivated and experienced Senior Scientist to join our CNS Biology team at Atlas Venture. As a key member of our team, you will be responsible for designing and executing in vitro and in vivo studies to advance our RNA editing therapeutics for neurodegenerative diseases.Key ResponsibilitiesDesign and conduct RNA editing...


  • Cambridge, Massachusetts, United States Synectics Inc Full time

    Job OverviewPosition Summary: This role is pivotal in leveraging molecular biology knowledge to foster advancements in the engineering and development of cutting-edge RNA therapeutics, including circRNA and saRNA. Collaborate within a vibrant team of forward-thinking scientists to enhance RNA design, stability, and translation efficiency. Investigate and...


  • Cambridge, Massachusetts, United States Sail Biomedicines Full time

    About Sail:Sail Biomedicines is harnessing evolutionary and artificial intelligence to revolutionize programmable medicines. Sail's platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines...


  • Cambridge, Massachusetts, United States Flagship Ventures Full time

    Join a Pioneering OrganizationImagine being part of a company that not only creates but also resources and develops life sciences ventures that innovate groundbreaking technologies aimed at transforming healthcare.The ChallengeIn the current healthcare landscape, diagnosing diseases frequently involves invasive methods, such as biopsies, which allow for...


  • Cambridge, Massachusetts, United States GC Therapeutics Full time

    In Vivo Research ScientistCompany OverviewGC Therapeutics is pioneering the exploration of genome-wide cell landscapes through an innovative synthetic biology and AI-driven platform for cell programming. Our proprietary pluripotent stem cell differentiation technology, TFomeTM, was developed in collaboration with Professor George Church's lab, a leader in...


  • Cambridge, Massachusetts, United States American Society of Plant Biologists Full time

    About the RoleWe are seeking a highly skilled Senior Research Scientist, Plant Molecular Biology Specialist to join our team at the American Society of Plant Biologists. As a key member of our research team, you will be responsible for leading the development of our plant cell culture platform and driving innovation in plant molecular biology.Key...


  • Cambridge, Massachusetts, United States GlaxoSmithKline Full time

    Site Name: Cambridge Binney StreetPosted Date: Aug 1 2024Job Title: Scientist, Preclinical Molecular Biology - MAPS Vaccine PlatformCompany: GSK (GlaxoSmithKline)Location: Binney Street, Cambridge, MAJob Type: Full-timeAt GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is...


  • Cambridge, Massachusetts, United States Flagship Ventures Full time

    Position Overview:We are in search of a dynamic and driven scientist with substantial expertise in computational structural biology, coupled with outstanding AI/ML computational and programming capabilities. This role is pivotal in providing strategic vision, innovative thinking, and critical insights for the advancement of novel protein-based therapies at...


  • Cambridge, Massachusetts, United States FogPharma Full time

    About the RoleFogPharma is a pioneering biopharmaceutical company that is revolutionizing the medical possibilities for patients by precisely drugging intracellular targets. We are seeking a highly motivated Senior Associate Scientist with experience in cellular and molecular biology techniques for drug discovery.Key ResponsibilitiesDevelop and Perform...


  • Cambridge, Massachusetts, United States Merck Full time

    Job DescriptionOur company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us. Our ability to excel depends on the...

  • Principal Scientist

    1 month ago


    Cambridge, Massachusetts, United States Nuvalent, Inc Full time

    Reporting to the VP, Medicinal Chemistry, the Principal Scientist, Medicinal Chemistry will have strong technical and problem-solving skills in organic and medicinal chemistry skills.The scientist in this position will work with the Nuvalent team, including the scientific founder, and will be responsible for leading medicinal chemistry efforts on at least...


  • Cambridge, Massachusetts, United States Sail Biomedicines Full time

    About Sail:Sail Biomedicines is harnessing evolutionary and artificial intelligence to revolutionize programmable medicines. Sail's platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines...


  • Cambridge, Massachusetts, United States Biogen Full time

    Join Biogen's Team of Innovative ResearchersAbout BiogenBiogen is a leading biopharmaceutical company dedicated to developing innovative therapies for serious neurologic diseases. Our research focuses on uncovering the underlying biology of complex diseases, driving us to push the boundaries of scientific knowledge.Our Research in Chemical BiologyWe are...

  • Research Scientist

    1 week ago


    Cambridge, Massachusetts, United States Cynet Systems Inc. Full time

    Job SummaryCynet Systems Inc. is seeking a highly skilled Research Scientist to join our team. As a Research Scientist, you will be responsible for conducting research and development in the field of biology and molecular/cell biology.Key ResponsibilitiesConduct Research and Development: Design, develop, and implement new research protocols and methods to...


  • Cambridge, Massachusetts, United States Third Rock Ventures Full time

    Lead Scientist in Biological ResearchAn innovative startup backed by Third Rock Ventures is transitioning from stealth mode and is on the lookout for a skilled Lead Scientist to join its pre-clinical Biology team. This role will focus on a discovery-stage pipeline targeting antibody-related diseases. The Lead Scientist will be responsible for spearheading in...


  • Cambridge, Massachusetts, United States Third Rock Ventures Full time

    In Vivo Pharmacology ScientistA pioneering and well-capitalized startup, backed by Third Rock Ventures, is transitioning from stealth mode and is on the lookout for a skilled Scientist to enhance the Biology - In Vivo Pharmacology team. This role is crucial as the Scientist will act as the in vivo pharmacology expert for discovery-stage pipeline initiatives...