Research Scientist I/II in Automation

1 week ago

Cambridge, Massachusetts, United States Repertoire Immune Medicines Full time
Job Overview

Position: Research Associate I/II
Focus Area: Automation & Next-Generation Sequencing (NGS)

Company Background:
Repertoire Immune Medicines is a pioneering biotechnology firm dedicated to harnessing the extraordinary capabilities of the human immune system to combat cancer, autoimmune disorders, and infectious diseases. Founded by Flagship Pioneering, the company operates on the premise that a deep understanding of T cell receptor (TCR)-antigen immune interactions is pivotal for groundbreaking advancements in medical science. The innovative DECODETM platform developed by Repertoire enables comprehensive analysis of TCR-antigen pairs, facilitating the creation of novel targeted immune therapies aimed at reprogramming the immune system to eliminate tumors or restore immune balance.

Work Environment:
This position requires on-site presence in a collaborative setting.

Role Summary:
We are in search of a motivated Research Associate I/II (RA) to become a vital member of our Platform Discovery Team. The RA will be instrumental in preparing essential reagents for DECODE assays, ensuring the quality of produced materials, and conducting next-generation sequencing experiments. Responsibilities will encompass both manual tasks and the operation of liquid handling equipment. The ideal candidate will work closely with a diverse team of immunologists, molecular biologists, and protein scientists to effectively execute experiments and enhance processes.

Key Responsibilities:

  • Generate, purify, and maintain in-house materials essential for DECODE platform operations.
  • Prepare reagents through manual pipetting techniques.
  • Utilize liquid handling robots for high-throughput material production.
  • Collaborate with scientific teams to perform single-cell and bulk sequencing experiments aligned with project goals.
  • Extract DNA/RNA from human samples and prepare sequencing libraries for various analyses.
  • Conduct quality control assessments, including qPCR and gel electrophoresis, to ensure data integrity.
  • Perform routine maintenance on specialized laboratory equipment, including sequencing instruments.
  • Collaborate with the Platform Team to evaluate process outputs and present findings at departmental meetings.
  • Manage inventory and order critical reagents to support project timelines.

Qualifications:

  • Bachelor's or Master's degree in a scientific discipline or health-related field.
  • Up to 2+ years of relevant research experience in industry or academia.
  • Strong foundation in molecular biology and laboratory techniques (PCR, qPCR, ddPCR, nucleic acid purification).
  • Familiarity with single-cell methodologies (e.g., 10X Genomics, Smart-Seq).
  • Experience with liquid handling systems is advantageous.
  • Ability to prioritize tasks effectively and meet deadlines.
  • Basic understanding of genetics, immunology, and cancer biology.
  • Critical thinking skills and ability to work independently.
  • Exceptional documentation and attention to detail.
  • Strong written and verbal communication abilities.

Repertoire is committed to fostering an inclusive culture and recognizes the value of diverse perspectives in driving innovation. We actively pursue equity in all aspects of the work experience and strive to educate ourselves about societal inequities to effect positive change.

Repertoire is proud to be an Equal Opportunity Employer.

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