Lead Scientist, Biomarker Development

7 days ago


Cambridge, Massachusetts, United States Novartis Farmacutica Full time
Job Summary

We are seeking a highly skilled Senior Research Scientist to join our Clinical Genetics and Genomics team at Novartis Farmacutica. As a key member of our team, you will be responsible for developing and implementing innovative genetic and genomic biomarker assays, including targeted and NGS-based technologies.

Key Responsibilities
  • Develop, validate, and implement genetic and genomic biomarker assays, including RT-qPCR, ddPCR, DNAseq, and RNAseq for clinical studies.
  • Generate, QC, and analyze data to enable proof of mechanism, dose selection & proof of biology across early clinical programs and present results at internal meetings.
  • Conduct large RNAseq data analysis focusing on differential gene expression profiles.
  • Partner with outsourcing functions to evaluate new CROs and new modalities that support genetic and genomic biomarker activities in clinical studies.
  • Conduct activities according to the appropriate SOPs and guidelines in compliance with Novartis quality expectations and Values and Behaviors.
  • Develop knowledge in additional biomarker modalities and/or technologies.
  • Network internally and externally to expand scientific and technical knowledge.
Requirements
  • PhD degree in Biology, Immunology, or Cell Biology required plus 3 years of relevant professional experience (including post-doctoral work) desirable.
  • Experience in PCR-based assays development (e.g., qPCR, ddPCR) and related software analysis.
  • Experience in profiling genomic technologies, such as RNAseq, scRNAseq, and/or DNAseq.
  • Proficient in RNAseq data analysis focusing on differential gene expression analysis.
  • Professional experience in the pharmaceutical or biotechnology environment is preferred, particularly in clinical biomarker development and bioanalytical assays for genetic and genomic biomarkers.
  • Competent in nucleic acid extractions from human clinical samples (whole blood, tissues & other body fluids).
  • Ability to communicate effectively with excellent presentation skills.


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