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Senior Associate Scientist in Translational Medicine and Imaging Biomarkers
2 months ago
Biogen's Translational Medicine Biomarkers Imaging division is at the forefront of a cutting-edge molecular imaging research initiative, focusing on the discovery and evaluation of radiotracers and methodologies applicable to drug development.
Key Responsibilities
We are in search of a dedicated scientist with a strong background in both plate-based and tissue-based pharmacology techniques utilizing radioligands in various biological systems, both in vitro and in vivo. The role will primarily be laboratory-focused (80-90%) and will involve close collaboration with other Imaging team members as well as cross-functional program teams.
- Assess the pharmacological properties of leading small molecules in vitro and in vivo using diverse molecular imaging techniques.
- Employ radiolabeled compounds such as [3H] and [18F] to conduct molecular pharmacology assays.
- Perform in vitro and ex vivo radioligand binding for plate-based and autoradiographic brain imaging.
- Process human and rodent tissues, including cryostat brain slicing and homogenate preparation for protein target isolation.
- Develop assays and methodologies for plate-based and ex vivo brain imaging studies.
- Handle animals, including brain dissection and administration of compounds or radioisotopes.
- Utilize target identification techniques such as immunohistochemistry (IHC) and immunofluorescence.
- Present findings at team meetings and internal forums.
Candidate Profile
The ideal candidate is a highly motivated, results-driven scientist with excellent communication skills who thrives in a collaborative setting. You will support a team of scientists in the preclinical discovery of innovative Biomarker PET tracers for clinical trials focused on neurological disorders.
Qualifications
Required:
- Bachelor’s degree with a minimum of 4-6 years of industry experience in pharmaceuticals/biotechnology or a CRO, or a Master’s degree with at least 2-4 years of relevant experience.
- Proficiency in plate-based pharmacology techniques.
- Experience in compound handling and solution preparation.
- Knowledge of radioisotope handling.
- Background in assay development and optimization.
- Experience with rodent handling, compound dosing, and tissue dissection.
- Familiarity with immunohistochemistry (IHC) techniques for target detection in brain slices.
Preferred:
- Understanding of therapeutic areas in neurology, particularly neurodegenerative diseases.
Why Choose Biogen?
At Biogen, we are a global team committed to excellence and innovation. As a mid-sized biotechnology firm, we offer the stability and resources of an established organization while promoting an environment where individual contributions are valued.
Our team consists of some of the most talented and passionate professionals, providing unparalleled opportunities for learning, growth, and skill enhancement. Together, we strive to deliver life-changing therapies, with every role playing a crucial part in our mission. We are dedicated to fostering a culture of inclusion and belonging that reflects the diverse communities we serve.
We recognize that diverse backgrounds, cultures, and perspectives strengthen our company and drive innovation, and we are focused on building teams where every employee feels empowered and inspired.
