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Lead Scientist in Clinical Genetics and Genomics

2 months ago

Cambridge, Massachusetts, United States Novartis Farmacéutica Full time
Position Overview:

As a Lead Scientist specializing in Clinical Genetics and Genomics, you will play a pivotal role in our Biomarker Development team. This position emphasizes hands-on experience in crafting and executing genetic and genomic assays, including both targeted and next-generation sequencing (NGS) technologies.

Your analytical skills will be essential for processing and interpreting complex data, particularly in the realm of differential gene expression analysis derived from RNA sequencing.

Key Responsibilities:
  • Design, validate, and implement cutting-edge genetic and genomic biomarker assays, such as RT-qPCR, ddPCR, DNA sequencing, and RNA sequencing for clinical applications.
  • Generate, perform quality control, and analyze data to support proof of mechanism, dose selection, and biological validation across early-stage clinical programs, presenting findings in internal forums.
  • Conduct comprehensive RNA sequencing data analysis with a focus on differential gene expression profiles.
  • Collaborate with external partners to assess new contract research organizations (CROs) and innovative methodologies that enhance genetic and genomic biomarker initiatives in clinical trials.
  • Execute tasks in alignment with established standard operating procedures (SOPs) and regulatory guidelines, adhering to Novartis quality standards and core values.
  • Expand expertise in additional biomarker modalities and technologies.
  • Engage with both internal and external networks to broaden scientific and technical knowledge.
Qualifications:

A PhD in Biology, Immunology, or Cell Biology is required, accompanied by a minimum of three years of relevant professional experience, including post-doctoral research.

Proficiency in the development of PCR-based assays (e.g., qPCR, ddPCR) and familiarity with associated software for data analysis.

Experience with genomic profiling technologies, including RNA sequencing, single-cell RNA sequencing, and DNA sequencing.

Strong capabilities in RNA sequencing data analysis, particularly in the context of differential gene expression.

Previous experience in the pharmaceutical or biotechnology sectors is highly desirable, especially in clinical biomarker development and bioanalytical assays for genetic and genomic biomarkers.

Skilled in nucleic acid extraction from human clinical specimens (e.g., whole blood, tissues, and other bodily fluids).

Excellent communication skills with a proven ability to present complex information effectively.

Commitment to Diversity and Inclusion:

Novartis is dedicated to fostering an inclusive work environment and building diverse teams that reflect the patients and communities we serve.

Equal Opportunity Statement:

The Novartis Group of Companies is an Equal Opportunity Employer and takes pride in maintaining a diverse workplace.

We do not discriminate in recruitment, hiring, training, promotion, or other employment practices based on race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility and Reasonable Accommodations:

The Novartis Group of Companies is committed to working with and providing reasonable accommodations to individuals with disabilities.