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Principal Scientist, Modeling and Simulation
2 months ago
About the Role
We are seeking a highly skilled Translational Modeler to join our team at Novartis Group Companies. As a key member of our Radioligand Modeling and Simulation team, you will play a critical role in accelerating radioligand discovery and development by facilitating rigorous decision-making with modeling and simulation.
Key Responsibilities
- Develop and execute modeling strategies to support radioligand therapy programs, contributing to project team discussions and guiding therapeutic design and dose selection decisions.
- Build and apply innovative Quantitative Systems Pharmacology (QSP) and physiologically based PK (PBPK) models to link RLT pharmacology, tissue biodistribution, mechanism(s) of action, and biological and clinical outcomes.
- Contribute to an integrated RLT modeling platform that bridges data and knowledge across preclinical species and patients, partnering with discovery project teams and the preclinical safety and pharmacometrics groups.
- Implement innovative quantitative approaches to advance the translational science for radiopharmaceuticals.
- Proactively seek opportunities to increase the impact and awareness of translational and clinical modeling through communications with internal and external audiences.
Essential Requirements
- Ph.D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field, with demonstrated expertise in radiobiology/nuclear medicine.
- Prior experience in pharmacokinetics and pharmacodynamics (PK/PD), QSP, and/or PBPK modeling is preferred.
- Expert-level proficiency in core modeling fundamentals, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization.
- Demonstrated ability to communicate modeling results to a multidisciplinary audience to facilitate decision-making.
- Fluent in English (oral and written).
What We Offer
At Novartis Group Companies, we offer a dynamic and inclusive work environment, with opportunities for professional growth and development. We are committed to building diverse teams, representative of the patients and communities we serve. Our compensation and benefits package includes a competitive salary, comprehensive benefits, and a range of perks and rewards.
