Principal Oligo Data Scientist
4 weeks ago
As a Principal Oligo Data Scientist at GlaxoSmithKline, you will play a key role in the design, characterization, and early development of oligonucleotide therapies. You will work closely with the Oligo Sciences team to co-develop a data capture and analysis platform, and translate their needs to build methods, models, and capabilities that fulfill them.
Key Responsibilities:
Co-develop a target/complex engagement model that combines target sequence, secondary+ tertiary structure, and oligo chemistry to drive binding assay designs for both high-throughput screening and low-latency optimization.
Co-design and implement a target tractability system for oligo-guided therapeutic mechanisms such as RNA degradation/interference, and up/down modulation of alternative splicing, poly-adenylation, A>I editing, etc.
Requirements:
MS degree in computational life science (bio/med/chem/stats/informatics) with at least 1 published work and 5+ years of industry experience.
PhD degree in computational life science (bio/med/chem/stats/informatics) with at least 1 published work and 2+ years industry, post doc, or internship experience.
1+ year experience with Cheminformatic or structural modelling of drug-target binding for small or large molecules validated by real qSAR assays.
1+ year experience with genomic data infrastructure for either public or private collections (e.g. ENCODE, TCGA, DepMap, GTEx, cellXgene, UK biobank).
Preferred Qualifications:
Performed target identification or tractability/prioritization for RNA-modulating approaches or RNA-targeted modalities.
Demonstrated cross-functional communication, matrixed collaboration, both team and thought leadership.
About GSK:
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
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