Lead Scientist in Bio-conjugation
2 weeks ago
Position: Senior Bio-conjugation Research Scientist
Location: South San Francisco, CA
Contract Duration: 12 months
Compensation: $66/hr
Overview:
This role is for a Senior Bio-conjugation Research Scientist.
• A minimum of 8 years of pertinent industry experience is required, with a Bachelor's or Master's degree, or 5 years with a PhD.
Essential Qualifications:
• Proficient in the conjugation, purification, and characterization of antibody-drug conjugates, alongside familiarity with analytical methodologies and instrumentation, including chromatographic techniques such as Hydrophobic Interaction Chromatography (HIC), Reverse Phase (RP), Size Exclusion Chromatography (SEC), SDS-PAGE, and UV-Vis spectroscopy.
• Preferred Skills: Experience in biologics analytics and purification methodologies.
• Required Expertise: Background in bio-conjugation, protein biochemistry, and chemistry.
Candidate Profile: A collaborative team player who adheres to timelines and possesses strong communication skills.
Note: This is an onsite, laboratory-focused position with potential for extension.
Key Responsibilities:
The successful candidate will be part of a dynamic Discovery Chemistry team.
• Engage in multidisciplinary collaborations to develop innovative therapeutic solutions by utilizing optimized conjugation protocols, analytical techniques, and data interpretation to synthesize drug candidates and intermediates.
• Demonstrate excellent interpersonal, collaborative, and communication abilities within a team-oriented environment.
• Expected to rapidly acquire skills through hands-on training, becoming increasingly proficient and autonomous in reaction setup, route design, and optimization.
Educational Background:
• Candidates should possess a B.S., M.S., or PhD in chemistry, biochemistry, or a related discipline, with relevant industrial or academic experience.
Experience and Skills Required:
• Practical experience in conjugation, purification, and characterization of antibody-drug conjugates, with proficiency in analytical techniques and instrumentation, including chromatographic methods such as HIC, RP, SEC, SDS-PAGE, and UV-Vis.
Specific Duties Include:
• Conducting bioconjugations of linker-payload combinations to antibodies using established in-house methods.
• Selecting and implementing suitable purification techniques for biologics, including SEC, hydrophobic interaction chromatography, and ion exchange chromatography.
• Gathering and analyzing analytical data, such as LC/MS.
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