Principal Research Scientist
6 days ago
Our Mission: Engage Bio is a biotechnology company developing a new class of genetic medicines. Our Tethosome platform addresses the challenges of non-viral DNA therapies: low expression and toxicity caused by innate immune detection. Tethosomes achieve higher expression than traditional DNA and evade detection by the innate immune system, enabling potent and safe non-viral DNA therapies. The programmability and specificity of Tethosomes enable broad therapeutic applications ranging from gene replacement to cancer immunotherapy.
Our Work: It's an exciting, fast-paced, and rewarding environment. We believe that improving patients' lives is the most valuable goal we can strive for - and we're looking for others who share our passion.
The Role: We're seeking a Senior/Principal Research Scientist to join our team and contribute to our research efforts. You will be responsible for generating clear data packages to communicate results and inform decision-making. You will also research novel assays and technologies to help improve and accelerate Engage Bio's workflow. Projects will include developing, running, and analyzing in vitro assays, optimizing lipid nanoparticle formulations, and supporting the team in any way possible. As we're a fast-growing company, this role is flexible and offers exposure to various aspects of preclinical and early clinical drug development.
Your Experience: A PhD in Chemistry, Biology, or a related field with 4-8+ years of experience is required. This role demands extensive experience in assay development or lipid nanoparticle formulation and a willingness to become an expert in other areas. Experience in mammalian cell culture, flow cytometry, ELISAs, high-throughput cell-based assays, lipid nanoparticle (LNP) formulation, and LNP characterization is desirable.
What We're Looking For: We're passionate about improving patients' lives and looking for teammates who will have a similar sense of ownership over our collective efforts. Key attributes we're seeking include flexibility, efficiency, organization, motivation to independently drive projects, and a shared sense of purpose.
Benefits: This role offers a unique opportunity to join a fast-paced startup environment and be a key contributor to the development of next-generation genetic medicines. We provide strong equity incentives, health and dental benefits, and generous PTO. We're located in the Bay Area at MBC BioLabs in San Carlos, a collaborative hub of innovative scientists and startups.
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