Senior Bio-conjugation Research Scientist

2 months ago


South San Francisco, California, United States eTeam Full time

Position: Senior Bio-conjugation Research Scientist

Location: South San Francisco, CA

Contract Duration: 12 months

Compensation: $66/hr

Overview:

This role is for a Senior Bio-conjugation Research Scientist within the Discovery Chemistry team at eTeam.


• A minimum of 8 years of pertinent industry experience is required, with a Bachelor's or Master's degree, or 5 years with a PhD.

Essential Qualifications:


• Proven expertise in the conjugation, purification, and characterization of antibody-drug conjugates, alongside proficiency in analytical methodologies and instrumentation, including chromatographic techniques such as HIC (Hydrophobic Interaction Chromatography), RP (Reverse Phase), SEC (Size Exclusion Chromatography), SDS-PAGE, and UV-Vis.


• Preferred Skills:
Experience in biologics analytics and purification methodologies.


• Required Knowledge:
Strong background in bio-conjugation, protein biochemistry, and chemistry.

Personal Attributes: A collaborative team player who adheres to timelines and possesses strong communication skills.

Note: This is an onsite, laboratory-focused position with potential for extension.

Key Responsibilities:

The selected candidate will be part of a multidisciplinary team dedicated to discovering innovative medicines by implementing refined conjugation protocols, analytical techniques, and data interpretation to develop drug candidates and intermediates.


• Candidates must demonstrate exceptional interpersonal skills and the ability to work collaboratively within a team setting.


• It is anticipated that the successful candidate will rapidly acquire skills through hands-on training, becoming increasingly adept and self-sufficient in reaction setup, route design, and optimization.

Educational Background:


• Minimum qualifications include a B.S., M.S., or PhD in chemistry, biochemistry, or a related discipline, complemented by relevant industrial or academic experience.

Experience and Skills Required:


• Direct experience in the conjugation, purification, and characterization of antibody-drug conjugates, along with familiarity with analytical techniques and instrumentation, including chromatographic methods such as HIC, RP, SEC, SDS-PAGE, and UV-Vis.

Specific Duties Include:


• Conducting bioconjugations of linker-payload combinations to antibodies using established in-house methodologies.


• Selecting and applying suitable purification techniques for biologics, including SEC, hydrophobic interaction chromatography, and ion exchange chromatography.


• Gathering and analyzing analytical data, such as LC/MS.



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