Ion Channel Research Associate

2 weeks ago

St Louis, Missouri, United States Washington University in St. Louis Full time
Scheduled Hours
40

Position Overview
The Sah laboratory at Washington University School of Medicine in St. Louis (Department of Internal Medicine, Cardiology) and the Center for the Investigation of Membrane Excitability Disease (CIMED) focuses on the exploration of Transient Receptor Potential (TRP) and LRRC8a/SWELL1 ion channel dynamics and signaling pathways. Utilizing advanced methodologies such as electrophysiological techniques (including patch-clamp), imaging modalities, genetic mouse models (incorporating CRISPR/cas9 technology), as well as biochemical and molecular strategies, the laboratory investigates the regulatory mechanisms of novel ion channels, specifically TRP/LRRC8 channels, in various tissues including cardiac muscle, skeletal muscle, adipose tissue, endothelium, and pancreatic islet cells.

The primary objective of the Sah laboratory is to elucidate the influence of ion channels and mechanosensing on cellular and organismal metabolism. Additionally, we integrate medicinal chemistry with cryo-EM structural analysis, molecular docking, and functional assessments to facilitate the development of innovative ion channel modulators aimed at addressing human health challenges.

Job Responsibilities

Working Environment

The role is situated within a laboratory setting that may involve exposure to biological and chemical risks. The individual must be capable of wearing protective gear, providing standard care to research animals, and managing human biosamples.

Compensation Range

Salary is aligned with experience levels.

Preferred Qualifications
  • Solid foundation in cell biology and protein biochemistry, with a keen interest in electrophysiology and ion channel research.
  • Proficient in software applications (Excel, Photoshop, and Prism) and general laboratory apparatus.
  • Proven ability to work autonomously and communicate effectively.
  • Strong troubleshooting capabilities.
  • Ability to maintain thorough and organized documentation.
  • Excellent verbal, written, and interpersonal communication skills.
Required Qualifications

Bachelor's degree. Candidates with further education and experience are encouraged to submit their applications.

Grade Level
00

Pre-Employment Screening
All external candidates receiving an offer for employment will be required to undergo pre-employment screening for this position. The screenings will include criminal background checks and, as applicable for the position, other background checks, drug screening, verification of employment and education or licensure/certification, physical examination, certain vaccinations, and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Overview
Washington University in St. Louis is dedicated to offering a comprehensive and competitive benefits package to its employees. Benefits eligibility is contingent upon employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website to view a summary of benefits.

EEO/AA Commitment
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and particularly encourages applications from individuals belonging to underrepresented groups. The University’s policy is to provide equal opportunity and access to individuals in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.

Diversity Commitment
Washington University is devoted to fostering a diverse community of individuals who are committed to contributing to an inclusive environment, promoting respect for all, and welcoming individuals from varied backgrounds, experiences, and perspectives. Individuals who share this commitment are encouraged to apply.

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