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Neuroscience Research Fellow
2 months ago
Position Overview
The Williams Lab is in search of a dedicated postdoctoral researcher focused on the investigation of neuronal regeneration and preservation within retinal mouse models affected by injury and disease.
Project Focus
This research initiative will delve into the impact of trauma and degenerative diseases on retinal ganglion cells at the subcellular level, utilizing advanced in vivo imaging methodologies.
Key Responsibilities
The selected researcher will be tasked with:
- Establishing an adaptive optics module to enhance the existing 2-photon microscope for transpupillary imaging in murine models.
- Investigating the activity of genetically encoded biosensors localized to organelles.
- Imaging changes in retinal axons, dendrites, and glial processes in response to neurodegenerative conditions.
- Collecting and analyzing data, as well as preparing presentations and manuscripts.
Research Environment
The Williams Lab operates within the Washington University School of Medicine, aiming to uncover fundamental mechanisms of neuronal loss to better understand the reasons behind neuronal death or axonal damage. This knowledge is pivotal for developing innovative strategies aimed at the preservation or restoration of neural tissue.
Research Approaches
Our methodologies encompass various techniques, primarily focusing on:
- Mouse models of retinal ganglion cell neurodegeneration.
- In vivo microscopy.
- AAV-mediated gene delivery and knockout.
- Transcriptomic and immunohistological analyses.
Collaboration and Development
The postdoctoral researcher will have the opportunity to engage with the extensive Neuroscience community at Washington University School of Medicine. Our lab has established collaborations with experts in electrophysiology, large volume electron microscopy, and other fields to support independent research endeavors initiated by postdoctoral scholars.
Professional Growth
In addition to access to high-quality research facilities, the Office of Postdoctoral Affairs, Career Center, Teaching Center, and campus groups provide career and professional development training for postdoctoral researchers.
Primary Duties
The researcher will work under the guidance of a faculty mentor, managing their own project aimed at producing a first-author publication. Responsibilities include:
- Gaining expertise in isolation and transcriptomic analysis of retinal neurons.
- Employing surgical techniques for optic nerve injury and glaucoma in mice.
- Producing and applying adeno-associated viruses.
- Enhancing career skills such as writing, public speaking, networking, and critical evaluation of scientific literature.
- Presenting scientific findings both within and outside the university.
- Assisting in grant preparation and reporting.
- Designing and evaluating research experiments.
- Maintaining ethical standards and compliance with good laboratory practices.
Qualifications
Required: Ph.D., M.D., or an equivalent terminal or doctoral degree.
Preferred: Experience in adaptive optics microscopy and a proven ability to implement laboratory procedures and conduct research.
Working Conditions
This role is situated in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be capable of wearing protective equipment and providing standard care to research animals.
Benefits
Washington University in St. Louis is committed to offering a comprehensive and competitive benefits package to its employees, with eligibility contingent upon employment status and workload.
Diversity Commitment
Washington University is dedicated to fostering a diverse community of individuals who contribute to an inclusive environment, encouraging applications from those with diverse backgrounds, experiences, and perspectives.
