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Postdoctoral Research Fellow
2 months ago
We are seeking a highly motivated and experienced Postdoctoral Research Fellow to join our team at the Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine.
Key Responsibilities- Conduct cutting-edge research in the field of ion channels and membrane proteins, with a focus on investigating the fundamental mechanisms underlying ion channels of excitable membranes.
- Employ a multidisciplinary approach that combines structural biology, chemical biology, genetics, fluorescence microscopy, and electrophysiology.
- Collaborate with our team to develop and implement new research directions, including the use of advanced fluorescence microscopy techniques and state-of-the-art frequency-domain fluorescence lifetime imaging microscopy.
- Contribute to the preparation of research papers, presentations, and other scientific communications.
We are currently pursuing two main research directions:
Voltage-Sensing Mechanisms of Voltage-Gated Ion Channels- Investigate the mechanisms underlying voltage-gated ion channels that play a crucial role in various diseases, including chronic pain, cardiac arrhythmia, and epileptic seizures.
- Develop and apply advanced techniques, including patch-clamp fluorometry, Förster resonance energy transfer (FRET), and the use of fluorescent noncanonical amino acids.
- Elucidate the mechanisms involved in the lipid-mediated regulation of ion channels and the dynamics of lipid membranes, which are critical factors in inflammatory and neuropathic pain, Alzheimer's disease, epilepsy, and viral infections.
- Employ a range of techniques, including whole-cell fluorometry, calcium imaging, total internal reflection fluorescence (TIRF) microscopy, and fluorescence lifetime imaging.
- Ph.D. in a relevant field, such as biochemistry, molecular biology, or biophysics.
- Strong publication record in biophysics and biochemistry, with a focus on ion channels or membrane proteins.
- Experience in patch-clamp electrophysiology or fluorescence cell imaging using advanced fluorescence microscopy techniques.
- A competitive salary and benefits package.
- The opportunity to work with a talented team of researchers and contribute to cutting-edge research in the field.
- Access to state-of-the-art research facilities, including a frequency-domain fluorescence lifetime imaging microscopy.
