Principal Scientist, Protein Sciences

6 days ago


San Diego, United States Treelinebiosciences Full time

Treeline Biosciences was founded by an experienced team of biopharmaceutical scientists and executives committed to developing new medicines against compelling molecular targets in oncology. As a senior member of the Protein Sciences team, you will play an integral role supporting early-stage discovery programs by collaborating closely with a cross-functional team of scientists to impact small molecule drug discovery. In this role, you will report to the head of protein sciences and play a critical role to support early-stage drug discovery. Specifically, you will impact the target enabling strategy and design and implement gene-to-protein workflows to deliver high-quality protein for use in SAR enabling assays and structural biology efforts. As an integral part of project teams, you will drive lead discovery efforts by interpreting and integrating diverse data.

Responsibilities

  • Establish and implement strategies for enabling multiple protein targets.
  • Design, express, and purify protein targets to support structural biology and small molecule drug discovery efforts.
  • Manage and mentor PhD level Protein Scientists.
  • Perform functional and biophysical characterization of proteins using novel and established technical methods.
  • Interpret and integrate biochemical, biophysical and structural data to drive project decisions.
  • Collaborate across lead discovery, medicine design, and medicinal chemistry teams to efficiently drive projects forward.

Required Qualifications

  • PhD in Biochemistry, Biophysics, Structural Biology or related discipline with 2-3 years of relevant postdoctoral training.
  • 7+ years of experience in biotech/pharma industry with a track record of producing difficult proteins for small molecule drug discovery projects and interpreting diverse data to drive SAR. Relevant industry experience is a requirement for this role.
  • Experience and track record for managing PhD level scientists. Management experience is a requirement for this role.
  • Strong candidates will have a track record working with challenging protein targets and/or multi-protein complexes to enable assay development, structural biology and hit finding.
  • Proven hands-on experience with multiple expression platforms (e.g., bacteria, insect cell, mammalian cell) and proficiency with AKTA instrumentation and a broad range of standard and unique purification and protein QC techniques are required.
  • Previous experience in small molecule drug discovery, specifically biochemical assay development and characterization of small molecule inhibitors and protein-ligand binding interactions.
  • Strong candidates will have a track record integrating biochemical, biophysical and structural data to drive SAR and advance small molecule discovery from hit-finding to hit to lead stage.
  • Experience in a wide array of biochemical assays, both enzymatic and binding, such as FP, TR-FRET, AlphaScreen, DSF, SPR, ITC is a plus.
  • Candidates must possess excellent collaborative skills, demonstrate strong analytical and organizational skills, and work effectively under deadlines.
  • This role requires excellent communication skills and the ability to report and present data to colleagues and senior leadership.
#J-18808-Ljbffr

  • San Diego, United States Treeline Biosciences Full time

    Treeline Biosciences was founded by an experienced team of biopharmaceutical scientists and executives committed to developing new medicines against compelling molecular targets in oncology that have proven difficult to drug. We are pursuing a uniquely integrated approach that applies emerging scientific tools and a commitment to building our lead discovery...


  • San Diego, United States Bristol Myers Squibb Full time

    Principal Scientist, Membrane Protein Structural BiologyBMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases.Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale...

  • Research Scientist

    7 days ago


    San Mateo, California, United States Gilead Sciences Full time

    Job SummaryWe are seeking a highly motivated and detail-oriented Research Scientist to join our Cell Biology team in the Protein Sciences Core. As a Research Scientist, you will contribute to high-impact meaningful projects that will further advance our company's mission to cure cancer.Key ResponsibilitiesDesign and execute experiments to optimize...


  • San Diego, California, United States Treelinebiosciences Full time

    About the RoleTreeline Biosciences is a biopharmaceutical company dedicated to developing innovative medicines against challenging molecular targets in oncology. As a senior member of our Protein Sciences team, you will play a critical role in supporting early-stage discovery programs by collaborating closely with a cross-functional team of scientists to...


  • San Diego, United States Career Development Partners Full time

    Principal Scientist, Peptide Protein Chemistry This BioPharma is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options.We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric...


  • San Diego, California, United States Career Development Partners Full time

    Principal Scientist, Peptide Protein Chemistry This BioPharma is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options.We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric...


  • South San Francisco, United States QLSF Biotherapeutics, Inc. Full time

    Director / Sr. Scientist, Protein SciencesThis is a great opportunity to join the highly experienced scientific team at QLSF Biotherapeutics, an innovative immuno-oncology biotech in South San Francisco. We are seeking individual(s) with protein production, purification, and analytical characterization experiences, capable of advancing our pipeline in both...


  • South San Francisco, United States QLSF Biotherapeutics, Inc. Full time

    Director / Sr. Scientist, Protein SciencesThis is a great opportunity to join the highly experienced scientific team at QLSF Biotherapeutics, an innovative immuno-oncology biotech in South San Francisco. We are seeking individual(s) with protein production, purification, and analytical characterization experiences, capable of advancing our pipeline in both...


  • San Diego, California, United States Johnson & Johnson Full time

    About the RoleWe are seeking a highly skilled Principal Scientist, Discovery Data Science to join our team at Johnson & Johnson. As a key member of our Therapeutics Discovery organization, you will play a critical role in advancing our Artificial Intelligence/Machine Learning (AI/ML) capabilities for Drug Discovery.Key ResponsibilitiesDevelop and apply...


  • South San Francisco, California, United States Amgen Full time

    HOW MIGHT YOU DEFY IMAGINATION?Youve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology...


  • South San Francisco, United States Evercrisp Biosciences Full time

    About Us Evercrisp Biosciences, founded by world-renowned scientists who bring expertise and proprietary technology to the company, is currently operating in stealth mode with a substantial Series A commitment from Apple Tree Partners (ATP) to take the company from discovery to proof of concept. Evercrisp is initially focused on high-confidence,...


  • San Diego, California, United States Treeline Biosciences Full time

    Job SummaryTreeline Biosciences is seeking a highly experienced Senior Protein Scientist to join our Protein Sciences team. As a key member of our early-stage discovery programs, you will play a critical role in supporting the development of new medicines against challenging molecular targets in oncology.Key ResponsibilitiesDevelop and implement strategies...


  • San Diego, California, United States Treeline Biosciences Full time

    About the RoleWe are seeking a highly skilled Senior Protein Scientist to join our Protein Sciences team at Treeline Biosciences. As a key member of our team, you will play a critical role in supporting early-stage discovery programs by collaborating closely with a cross-functional team of scientists to impact small molecule drug discovery.Key...


  • san diego, United States Yoh, A Day & Zimmermann Company Full time

    Yoh has an exciting, opportunity for Plant Protein Scientist to join our rapidly growing biotech client based in San Diego, CA. This position will execute and lead in the lab efforts to discover next generation gene editing targets that will improve plant health and increase agricultural sustainability by improving crop resistance to disease and pests. The...


  • San Diego, United States Yoh, A Day & Zimmermann Company Full time

    Yoh has an exciting, opportunity for Plant Protein Scientist to join our rapidly growing biotech client based in San Diego, CA. This position will execute and lead in the lab efforts to discover next generation gene editing targets that will improve plant health and increase agricultural sustainability by improving crop resistance to disease and pests. The...


  • South San Francisco, California, United States Planet Pharma Full time

    Position: Junior Protein Formulation ScientistPlanet Pharma is in search of a Junior Protein Formulation Scientist to enhance their research team. The successful applicant will engage in the formulation of both liquid and lyophilized protein therapeutics, as well as the preparation of formulation and assay buffers, including containers and closures essential...

  • Principal Scientist

    2 months ago


    San Diego, United States Abbott Full time

    The Opportunity This position works out of our San Diego, CA location in the Infectious Diseases Division. We are seeking an experienced Principal Scientist to oversee and conduct cutting-edge research in enzymology, to identify, characterize, optimize and develop proteins used for nucleic acid amplification and sample preparation technologies....


  • San Diego, California, United States Scripps Research Full time

    About Us:Scripps Research is a leading nonprofit biomedical institute dedicated to advancing the understanding of life and improving human health. Our mission is to make a significant impact on the world through innovative research and education.Our Research:The Zhu Lab at Scripps Research is focused on developing vaccines for diverse viral pathogens,...

  • Principal Scientist

    1 month ago


    San Diego, United States Abbott Laboratories Full time

    Working at AbbottAt Abbott, you can do work that matters, grow, and learn, care for yourself and family, be your true self and live a full life. You’ll also have access to:Career development with an international company where you can grow the career you dream of!Free medical coverage for employees* via the Health Investment Plan (HIP) PPOAn excellent...

  • Principal Scientist

    1 month ago


    San Diego, United States Abbott Laboratories Full time

    Abbott is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnostics, medical devices, nutritionals and branded generic medicines. Our 114,000 colleagues serve people in more than 160 countries.Working at...