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Protein Sciences Team Lead
2 months ago
We are seeking a highly skilled Senior Protein Scientist to join our Protein Sciences team at Treeline Biosciences. As a key member of our team, you will play a critical role in supporting early-stage discovery programs by collaborating closely with a cross-functional team of scientists to impact small molecule drug discovery.
Key Responsibilities- Establish and implement strategies for enabling multiple protein targets.
- Design, express, and purify protein targets to support structural biology and small molecule drug discovery efforts.
- Manage and mentor PhD level Protein Scientists.
- Perform functional and biophysical characterization of proteins using novel and established technical methods.
- Interpret and integrate biochemical, biophysical and structural data to drive project decisions.
- Collaborate across lead discovery, medicine design, and medicinal chemistry teams to efficiently drive projects forward.
- PhD in Biochemistry, Biophysics, Structural Biology or related discipline with 2-3 years of relevant postdoctoral training.
- 7+ years of experience in biotech/pharma industry with a track record of producing difficult proteins for small molecule drug discovery projects and interpreting diverse data to drive SAR.
- Relevant industry experience is a requirement for this role.
- Experience and track record for managing PhD level scientists. Management experience is a requirement for this role.
- Proven hands-on experience with multiple expression platforms (e.g., bacteria, insect cell, mammalian cell) and proficiency with AKTA instrumentation and a broad range of standard and unique purification and protein QC techniques.
- Previous experience in small molecule drug discovery, specifically biochemical assay development and characterization of small molecule inhibitors and protein-ligand binding interactions.
- Experience in a wide array of biochemical assays, both enzymatic and binding, such as FP, TR-FRET, AlphaScreen, DSF, SPR, ITC.
This role requires excellent communication skills and the ability to report and present data to colleagues and senior leadership. The anticipated annual base salary range for candidates who will work in San Diego is $166,432 to $180,250.
