Senior Scientist, Protein Science
2 months ago
About Us
Evercrisp Biosciences, founded by world-renowned scientists who bring expertise and proprietary technology to the company, is currently operating in stealth mode with a substantial Series A commitment from Apple Tree Partners (ATP) to take the company from discovery to proof of concept. Evercrisp is initially focused on high-confidence, genetically validated but 'difficult to drug' targets in areas of high unmet need where genome editing can make a significant difference. At Evercrisp, innovation, collaboration, and commitment to making a significant impact on human health guide our work.
The Job
Evercrisp Biosciences invites highly motivated and qualified applicants for the position of Protein Scientist within our dynamic Protein Sciences team. The ideal candidate will bring deep-expertise in protein purification and play a key role in designing and generating biomolecules that underlie the heart of Evercrisp's CRISPR gene editing technology. This position would support lead production for scales spanning from in vitro screening to in vivo preclinical disease models. The successful candidate is an independent, creative scientist who can manage all aspects of protein production projects to deliver on our current pipeline and to shape the future of our gene-editing platform.
Key Responsibilities:
- Exercise high-level of technical discretion on protein production projects, including conception, material generation, purification, and delivery of high-quality protein.
- Develop, optimize, scale-up and troubleshoot protein production workflows.
- Implement new technologies to optimize current workflows and expand platform capabilities.
- Manage biophysical characterization of protein materials.
- Bring expertise in developing biologics.
- Coordinate and communicate progress across project teams.
- Analysis and interpretation of experimental results and assisting in the preparation of scientific reports and presentations, in addition to maintaining a detailed scientific notebook.
Qualifications
- PhD with at least 3 years of industry experience OR Bachelor's/Master's degree in Biology, Biochemistry, or other related scientific discipline with 10+ years of industry experience.
- Strong expertise in protein purification methodologies (affinity chromatography, ion-exchange, hydrophobic interaction, and size-exclusion) including extensive experience in designing and troubleshooting protein purification schemes.
- Operation and maintenance of AKTA and/or BioRad NGC system.
- Deep expertise in bacterial expression – including expression optimization and process development from small scale purification to large scale protein production.
- Previous experience managing bioreactors or fermenters is desirable.
- Familiarity with mammalian or cell-free expression technology is a plus.
- Experience in molecular biology including gene design, vector construction, and DNA sequence analysis is required, preference for scar-less methods (Gibson, Golden Gate, recombineering).
- Candidate will ideally be comfortable using structural software (Pymol, Chimera) to guide protein design.
- Mastery of standard protein quality assessment techniques (SDS-PAGE, MALS, DLS, ELISA, BLI, enzyme-linked functional assays...).
- Special consideration for candidates with demonstrable experience in the preclinical development of biologics.
- Attention to detail with rigorous scientific thinking and clear communication supported by appropriate documentation.
- Creative mindset to tackle difficult problems and propose solutions, as well as prioritize tasks across multiple projects.
- Strong team player with a desire to contribute to innovative technologies and drive success in an early-stage company.
Why Evercrisp?
Joining Evercrisp means becoming part of a team dedicated to making a lasting impact on the future of genetic medicine. We offer a dynamic, innovative, and supportive environment where your work will directly contribute to groundbreaking advancements in CRISPR-based technologies.
At Evercrisp, we value diversity, encourage professional growth, and provide competitive benefits and compensation.
Evercrisp is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
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