Senior Protein Scientist

5 days ago

San Diego, California, United States Treelinebiosciences Full time
About the Role

Treeline Biosciences is a biopharmaceutical company dedicated to developing innovative medicines against challenging molecular targets in oncology. As a senior member of our Protein Sciences team, you will play a critical role in supporting early-stage discovery programs by collaborating closely with a cross-functional team of scientists to drive small molecule drug discovery.

Key Responsibilities
  • Target Enabling Strategy: Establish and implement strategies for enabling multiple protein targets, leveraging your expertise in protein expression, purification, and characterization.
  • Protein Design and Development: Design, express, and purify protein targets to support structural biology and small molecule drug discovery efforts, utilizing novel and established technical methods.
  • Team Leadership: Manage and mentor PhD-level Protein Scientists, providing guidance and support to ensure the success of our discovery programs.
  • Data Interpretation and Integration: Interpret and integrate biochemical, biophysical, and structural data to drive project decisions, collaborating with lead discovery, medicine design, and medicinal chemistry teams to efficiently drive projects forward.
Requirements
  • Education: PhD in Biochemistry, Biophysics, Structural Biology, or a related discipline, with 2-3 years of relevant postdoctoral training.
  • Industry Experience: 7+ years of experience in the biotech/pharma industry, with a track record of producing difficult proteins for small molecule drug discovery projects and interpreting diverse data to drive SAR.
  • Management Experience: Experience and track record of managing PhD-level scientists, with a strong ability to lead and motivate high-performing teams.
  • Technical Skills: Proven hands-on experience with multiple expression platforms (e.g., bacteria, insect cell, mammalian cell) and proficiency with AKTA instrumentation and a broad range of standard and unique purification and protein QC techniques.
  • Collaboration and Communication: Excellent collaborative skills, with the ability to work effectively under deadlines and communicate complex scientific data to colleagues and senior leadership.

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