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Principal Scientist, Membrane Protein Structural Biology

2 months ago

San Diego, United States Bristol Myers Squibb Full time

Principal Scientist, Membrane Protein Structural Biology

BMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases.

Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis. Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro. LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency. Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology. The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate. Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.

BMS is a leader in the discovery and development of novel therapies that exploit targeted protein degradation. Structural biology is critical to this work, and for other efforts across additional modalities and therapeutic areas. High-quality 3D structures of soluble proteins, protein complexes, and membrane proteins enable our scientists to understand mechanisms of action, design ligands or drug molecules, and make predictions about new biological targets for our drug discovery efforts.

Job Description

The successful candidate will conduct research within a talented group of scientists focused on targeted protein degradation (Protein Homeostasis Structural Biology) but will work across functions and therapeutic areas to enable structural studies of key membrane proteins. There is opportunity to have a real-time, high-value impact on the ongoing projects as well as chart the future of our research efforts by capitalizing on structural insights, for example, by uncovering mechanisms of action, defining binding modes, and identifying target degrons. This scientist will interface with chemistry, biology, proteomics, and CADD scientists working across BMS. We are seeking a passionate scientist who strives to bring impactful membrane protein structural biology insights to bear on a burgeoning portfolio of targets, across therapeutic areas, with the goal of bringing novel therapies to patients.

Job Responsibilities

  1. Plan and execute laboratory experiments with the goal of generating suitable membrane proteins for successful structure determination by cryo-electron microscopy and/or X-ray crystallography
  2. Collect data and determine structures of key membrane protein structures relevant to drug discovery
  3. Interact with drug discovery project teams, and participate in departmental meetings, to communicate structural results and assist in rational drug design
  4. Participate in departmental initiatives on cross-functional initiatives/work streams/ taskforces
  5. Work with managers and peers to develop innovative structural biology methodologies and approaches to enable drug discovery

Basic Qualifications

  • Bachelor's Degree with 8+ years of academic or industry experience
  • Or
  • Master's degree with 6+ years of academic or industry experience
  • Or
  • PhD with 4+ years of academic or industry experience and 2 years of leadership experience

Preferred Qualifications

  • A PhD and postdoctoral research with relevant training, and demonstrated expertise in Cryo-EM, with X-ray crystallography experience a plus
  • 4 + years of experience in an academic and/or industrial setting employing innovative strategies to structurally characterize membrane proteins, protein-protein complexes, and ligand binding of these proteins
  • In-depth knowledge of current practices, instrumentation, and issues for answering key structural biology questions
  • Extensive, hands-on experience with membrane protein expression, purification, and structure determination by Cryo-EM
  • Preference will be given to candidates with experience in expression, purification, and structure determination of GPCRs relevant to drug discovery
  • Strong written and oral communication skills to deliver scientific results and presentations clearly
  • Demonstrated ability to thrive in a multidisciplinary team and inspire mutually beneficial collaborations to drive the drug discovery process
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