Principal Scientist
1 month ago
The Opportunity
This position works out of our San Diego, CA location in the Infectious Diseases Division.
We are seeking an experienced Principal Scientist to oversee and conduct cutting-edge research in enzymology, to identify, characterize, optimize and develop proteins used for nucleic acid amplification and sample preparation technologies. Your expertise will be crucial in advancing our understanding of enzymatic processes and developing innovative solutions. You’ll collaborate with cross-functional teams, establish protocols, and drive scientific excellence.
Responsibilities
Lead protein characterization, optimization and development efforts, from design of experiments through laboratory studies
Perform kinetic, thermodynamic and structure-function studies
Apply computational modeling to drive protein characterization and optimization efforts
Initiate and oversee proteomics efforts in-house and via collaboration
Provide cloning, protein expression, separation and purification expertise
Implement mutagenesis studies to help characterize and optimize proteins of interest
Drive the introduction of new, optimized and/or modified proteins to improve product performance
Design and implement procedures, processes and key performance indicators to monitor, characterize and QC proteins
Provide high level analysis of experimental results
Provide written reports and oral presentations to executives
Ability to work as part of a team with excellent communication skills
Excellent communication and collaboration skills
Required Qualifications
Bachelor's Degree. in Biochemistry/Biophysics/Protein chemistry, or a closely related field and 10 years of experience in similar area.
Preferred Qualifications
Ph.D.in Biochemistry/Biophysics/Protein chemistry, or a closely related field and 10 years of experience.
Minimum ten years of full-time laboratory experience in an industrial setting
Hands-on expertise using kinetic, thermodynamic and structure-function experimental approaches
Expertise with computational modeling of proteins and protein/nucleic acid interactions to drive characterization of protein functionality and to drive the incorporations of protein modifications to improve/alter function
Extensive experience characterizing DNA/RNA interacting/binding proteins
Expertise in optimizing protein expression and purification methods
Expertise in developing, optimizing and performing in vitro enzymatic assays
Experience with high-throughput genetic/molecular screening a plus
Inventive, with ability to implement ideas in the laboratory
Strong problem-solving skills and the ability to analyze complex enzymatic processes
Extensive hands-on experience driving the analytical, biological and functional characterization of proteins
Expertise in computational structure/function modeling of DNA/RNA binding proteins
Track record of modifying and optimizing protein function to improve key performance characteristics
Ability to work as part of a team with excellent communication skills
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