Principal Scientist

1 month ago


San Diego, United States Abbott Full time

The Opportunity

This position works out of our San Diego, CA location in the Infectious Diseases Division.

We are seeking an experienced Principal Scientist to oversee and conduct cutting-edge research in enzymology, to identify, characterize, optimize and develop proteins used for nucleic acid amplification and sample preparation technologies. Your expertise will be crucial in advancing our understanding of enzymatic processes and developing innovative solutions. You’ll collaborate with cross-functional teams, establish protocols, and drive scientific excellence. 

Responsibilities

Lead protein characterization, optimization and development efforts, from design of experiments through laboratory studies

Perform kinetic, thermodynamic and structure-function studies

Apply computational modeling to drive protein characterization and optimization efforts

Initiate and oversee proteomics efforts in-house and via collaboration

Provide cloning, protein expression, separation and purification expertise

Implement mutagenesis studies to help characterize and optimize proteins of interest

Drive the introduction of new, optimized and/or modified proteins to improve product performance

Design and implement procedures, processes and key performance indicators to monitor, characterize and QC proteins

Provide high level analysis of experimental results

Provide written reports and oral presentations to executives

Ability to work as part of a team with excellent communication skills

Excellent communication and collaboration skills

Required Qualifications

Bachelor's Degree. in Biochemistry/Biophysics/Protein chemistry, or a closely related field and 10 years of experience in similar area.

Preferred Qualifications

Ph.D.in Biochemistry/Biophysics/Protein chemistry, or a closely related field and 10 years of experience.

Minimum ten years of full-time laboratory experience in an industrial setting

Hands-on expertise using kinetic, thermodynamic and structure-function experimental approaches

Expertise with computational modeling of proteins and protein/nucleic acid interactions to drive characterization of protein functionality and to drive the incorporations of protein modifications to improve/alter function

Extensive experience characterizing DNA/RNA interacting/binding proteins

Expertise in optimizing protein expression and purification methods

Expertise in developing, optimizing and performing in vitro enzymatic assays

Experience with high-throughput genetic/molecular screening a plus

Inventive, with ability to implement ideas in the laboratory

Strong problem-solving skills and the ability to analyze complex enzymatic processes

Extensive hands-on experience driving the analytical, biological and functional characterization of proteins

Expertise in computational structure/function modeling of DNA/RNA binding proteins

Track record of modifying and optimizing protein function to improve key performance characteristics

Ability to work as part of a team with excellent communication skills

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