Senior Scientist Myeloid Cell and Tissue repair

1 month ago

Cambridge, United States Pfizer Full time

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

The Discovery Myeloid & Tissue Remodeling Group in the Inflammation and Immunology Research Unit is seeking a motivated, innovative and enthusiastic researcher to join us in our mission to define myeloid cell functional phenotypes in homeostatic, inflammatory, and fibrotic conditions with the goal of delivering transformative medicines. This Senior Scientist will work in a matrixed structure within the department and support both in vitro and in/ex vivo studies that investigate mechanisms for the resolution of inflammation and fibrosis, and novel targets for portfolio entry. The ideal candidate will have a diverse biology and immunology background and a history of success in developing assays, implementing new technologies, and triaging problems in biological systems. The candidate will be a key contributor in delivering data and recommendations for decisions of proposed and active programs.This is an opportunity for the right candidate to join a highly collaborative team conducting innovative Discovery research in a super-charged industrial setting.

How You Will Achieve It

  • Plan and execute laboratory experiments to produce robust, decision-making data

  • Develop relevant in vitro assays to evaluate disease phenotypes in inflammatory and fibrotic diseases

  • Investigate novel pathways involved in wiring monocytes to homeostatic, inflammatory or fibrotic macrophages states

  • Lead evaluations and portfolio entry of new targets in inflammation and fibrosis for portfolio entry

  • Support in vitro, in/ex vivo multiparametric assays including high parameter flow cytometry, histology, mutliplex immunofluorescence, high content imaging, and biochemical assays

  • Run high-parameter tissue imaging to validate target expression and determine cell components and localization

  • Collaborate with other Discovery and Preclinical groups in I&I, as well as key individuals in relevant partner lines

  • Prepare and present experimental results to project teams, and publish and present externally

  • Maintain high quality experimental records within an electronic laboratory notebook

Qualifications

Must-Have

  • BA/BS plus 5 years of experience, MS plus 2-4 years of experience, PhD plus 0-2 years of industry or post-doctoral experience in biology or immunology with laboratory experience relevant to the position(Myeloid cell biology)

  • Must be scientifically self-motivated and capable of independently conceiving, conducting, and critically analyzing their own innovative research, with minimal supervision

  • Experience with human and murine monocyte culture and assay development

  • Expertise in core molecular biology skills (PCR, ELISA, WB/IP, plate-based Assays, DNA/RNA Isolation, scRNAseq library preparation)

  • Ability to conduct data analysis using Microsoft Excel, GraphPad Prism, FlowJo, or equivalent software

  • Experience with high-parameter flow cytometry, immunohistochemistry & immunofluorescence.

  • Ability to complete experiments and present results in individual and group settings

  • Ability to learn novel skills and flourish in a highly-matrixed organization, and to work on multidisciplinary teams

  • Ability to make recommendations to effectively resolve issues by using sound judgment that is consistent with standards, practices, policies, procedures, and regulations

  • Proven verbal and written communication skills, and ability to work in a collaborative team environment

Nice-to-Have

  • Experience with in vitro gene editing approaches

  • Experience with R and scRNAseq analysis

  • Experience with iPSC culture a plus

  • Proficiency with personal computers including word processing, spreadsheets, Excel, PowerPoint and relevant scientific software is desirable

  • Expertise in myeloid/stroma inflammation and fibrosis highly preferred

Job location: On premise with relocation support available

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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