Senior Associate Scientist

1 month ago

Cambridge, United States ClinLab Staffing Full time

Location: Cambridge, MA (Kendall Sq.)

About you

We are looking for an experienced, motivated Senior Associate Scientist/Principal Associate Scientist to join our growing team of passionate researchers focused on identifying potent tumor killing targets. We are seeking a talented and collaborative cell biologist/immunologist to perform and develop target validation in vitro assays. A successful candidate will work closely with team members to drive discovery and pre- development programs. Our dynamic and innovative culture favors highly organized candidates, eager to learn and confident to work across boundaries.

Job Responsibilities

  • Work internally with collaborators to advance novel targets to develop clinical candidates
  • Work with team of scientists in the design, execution, and analysis of in vitro cell-based assays to assess efficacy and MOA
  • Support immuno-assay development for target validation, MOA and functional screens for hit identification, and MOA and functional characterization of leads in vitro
  • Contribute effectively to meetings, patents, scientific publications, and company

Qualifications

  • MS in relevant scientific discipline with 2-5 years of laboratory experience in industry or academia or BS with >3 years of industry-relevant experience; immunology background is a plus
  • Experience in mammalian cell culture techniques: isolating primary cells and managing cell lines
  • Experience with human and/or mouse immune cell isolation and culture, experience with macrophages or other myeloid cells preferred
  • Experience with functional immune cell assays (such as activation, phagocytosis, and proliferation assays)
  • Experience with standard immuno-assays (ELISA and/or multiplex cytokine/chemokine detection via MSD, LUMINEX or Legendplex)
  • Able to work efficiently both independently and in a team environment, demonstration of quality, proficiency, and attention to details
  • Maintain clear and accurate records of experiments and analysis in electronic notebook
  • Excellent written and communication skills, ability to organize and present scientific data

Preferred Qualifications:

  • Cell and molecular biology skills for target validation and MOA such as western blotting, cell line engineering (CRISPR , lentiviral transduction), immunoprecipitation and immunofluorescence
  • Prior experience working with mouse tumor models
  • Hands-on experience in basic flow cytometry is a plus but not required'

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