Senior Principal Scientist, Pharmacology

3 hours ago


Cambridge, Massachusetts, United States Novartis Group Companies Full time
About the Role:

The Novartis Group of Companies is seeking a highly skilled and experienced Senior Principal Scientist to join our team in Cambridge, MA. As a key member of our dynamic and multi-disciplinary team, you will play a critical role in developing and applying in vivo models to evaluate novel cancer therapies in the early-stage drug discovery pipeline.

Key Responsibilities:
  • Design and execute pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept of new modalities.
  • Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, relevant biomarkers, and key translational questions.
  • Manage associate-level scientists and collaborate with cross-functional project teams.
  • Critically analyze and present results within a multidisciplinary team environment.
  • Careful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebook.
Requirements:
  • PhD with 8-12 years of relevant research experience as a postdoc or in the pharmaceutical/biotech industry, preferably in the field of cancer immunology.
  • Extensive experience in a variety of molecular biology and flow cytometric skills.
  • Strong knowledge of T-cell and/or myeloid biology.
  • Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models.
  • Expertise in cell culture, PCR, ELISA, western blot, and flow cytometry.
  • Strong analytical, communication (written and verbal), and organizational skills, including a proficiency with PowerPoint and commonly used data analysis programs, such as Excel and Prism.
Desirable Requirements:
  • A strong background and expertise in cancer immunology is preferred.


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