Senior Principal Scientist, Pharmacology
3 hours ago
The Novartis Group of Companies is seeking a highly skilled and experienced Senior Principal Scientist to join our team in Cambridge, MA. As a key member of our dynamic and multi-disciplinary team, you will play a critical role in developing and applying in vivo models to evaluate novel cancer therapies in the early-stage drug discovery pipeline.
Key Responsibilities:- Design and execute pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept of new modalities.
- Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, relevant biomarkers, and key translational questions.
- Manage associate-level scientists and collaborate with cross-functional project teams.
- Critically analyze and present results within a multidisciplinary team environment.
- Careful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebook.
- PhD with 8-12 years of relevant research experience as a postdoc or in the pharmaceutical/biotech industry, preferably in the field of cancer immunology.
- Extensive experience in a variety of molecular biology and flow cytometric skills.
- Strong knowledge of T-cell and/or myeloid biology.
- Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models.
- Expertise in cell culture, PCR, ELISA, western blot, and flow cytometry.
- Strong analytical, communication (written and verbal), and organizational skills, including a proficiency with PowerPoint and commonly used data analysis programs, such as Excel and Prism.
- A strong background and expertise in cancer immunology is preferred.
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Senior Principal Scientist, Pharmacology
5 days ago
Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob Description SummarySenior Principal Scientist, PharmacologyThis is a lab head-based position where the ideal candidate will lead the design and execution of anti-tumor efficacy and PK/PD studies that evaluate drug candidates in CDX, PDX, and syngeneic models.Key Responsibilities:Design and execute pre-clinical in vivo studies to explore novel hypotheses,...
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Principal Scientist
3 weeks ago
Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob SummaryWe are seeking an experienced Senior Principal Scientist or Principal Scientist to join our Oncology Research and Development team at Novartis Group Companies. The successful candidate will be responsible for developing and implementing pharmacokinetics and clinical pharmacology strategies to support the development of innovative medicines.Key...
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Cambridge, Massachusetts, United States Union Chimique Belge Full timePosition OverviewAs a key contributor at Union Chimique Belge, the Senior Scientist in Quantitative Clinical Pharmacology will play a pivotal role in advancing our understanding of pharmacokinetics and pharmacodynamics across various therapeutic areas.Key ResponsibilitiesLead quantitative clinical pharmacology initiatives for designated projects.Collaborate...
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Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob SummaryWe are seeking a highly skilled and experienced Senior Research Scientist to join our team at Novartis Group Companies. As a Principal Scientist I, Large Animal Pharmacology, you will play a key role in supporting drug discovery for obesity, atherosclerosis, and heart failure therapeutics.Key ResponsibilitiesDesign and execute experiments in large...
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In Vivo Pharmacology Scientist
4 weeks ago
Cambridge, Massachusetts, United States Third Rock Ventures Full timeIn Vivo Pharmacology ScientistA pioneering and well-capitalized startup, backed by Third Rock Ventures, is transitioning from stealth mode and is on the lookout for a skilled Scientist to enhance the Biology - In Vivo Pharmacology team. This role is crucial as the Scientist will act as the in vivo pharmacology expert for discovery-stage pipeline initiatives...
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Senior Scientist PK Sciences Oncology
2 weeks ago
Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob Description SummaryJob Title: Principal/Senior Principal Scientist PK Sciences OncologyJob Summary: We are seeking an enthusiastic and motivated PK Sciences project team representative to develop and implement DMPK and/or clinical pharmacology strategies to support the pursuit of transformative new medicines from early discovery through late clinical...
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Senior Scientist, Large Animal Pharmacology
4 weeks ago
Cambridge, Massachusetts, United States Novartis Farmacéutica Full timePosition Overview:As a Senior Scientist in Large Animal Pharmacology, you will play a pivotal role in advancing drug discovery initiatives targeting obesity, atherosclerosis, and heart failure. Your expertise will contribute to a comprehensive understanding of cardiovascular and metabolic diseases.Key Responsibilities:Collaborate with the CRO team to develop...
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Principal Scientist in Drug Development
3 weeks ago
Cambridge, Massachusetts, United States Newton Colmore Full timeAbout the RoleWe are seeking a highly experienced Senior DMPK and ADME Expert to join our research team at Newton Colmore. As a Principal Scientist in Drug Development, you will play a key role in designing and implementing in vivo PK studies, providing updates and results to research teams, and presenting strategies at governance interactions.Key...
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Cell Pharmacology Research Scientist
4 weeks ago
Cambridge, Massachusetts, United States Novartis International AG Full timePosition OverviewAs a Research Scientist specializing in Cell Pharmacology, you will play a crucial role in advancing our understanding of drug interactions at the cellular level. Your expertise will be essential in the following areas:Target Identification and Validation: Engage in projects aimed at identifying and validating new therapeutic...
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Scientist, In Vivo Pharmacology Specialist
4 days ago
Cambridge, Massachusetts, United States Vaxess Technologies Full timeScientist, In Vivo PharmacologyVaxess Technologies is a clinical-stage biotech company developing innovative vaccines and therapies using its proprietary MIMIXTM Microneedle Array Patch technology. We are seeking a talented individual with expertise in animal models, pharmacology, and immunology to join our core team of scientists and engineers.Key...
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Cell Pharmacology Research Scientist
1 month ago
Cambridge, Massachusetts, United States Novartis International AG Full timePosition OverviewAs a Research Scientist focusing on Cell Pharmacology, you will play a crucial role in advancing our understanding of drug interactions at the cellular level. Your expertise will contribute to various projects aimed at identifying and validating therapeutic targets.Key ResponsibilitiesConduct research on target identification and...
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Cell Pharmacology Research Scientist
1 month ago
Cambridge, Massachusetts, United States Novartis International AG Full timePosition OverviewAs a Research Scientist specializing in Cell Pharmacology, you will play a pivotal role in advancing our understanding of drug interactions and mechanisms. Your expertise will contribute to the identification and validation of therapeutic targets.Key ResponsibilitiesConduct innovative research on target identification and validation.Engage...
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Cambridge, Massachusetts, United States UCB Full timeImpact Patients Through Science POSITION OVERVIEW As a key member of our team, the Lead Scientist - Quantitative Clinical Pharmacology / PK-PD Specialist will concentrate on quantitative clinical pharmacology initiatives across various diseases and therapeutic domains. This role is pivotal in advancing both Early and Late Clinical Development at UCB,...
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Senior Scientist, Discovery Program Lead
2 weeks ago
Cambridge, Massachusetts, United States CAMP4 Therapeutics Full timeAbout the RoleCAMP4 Therapeutics is seeking a highly skilled and experienced scientist to lead our Discovery team in driving cutting-edge projects from target selection through development candidate selection. As a Principal Scientist, Discovery, you will be responsible for driving innovative science to develop antisense oligonucleotide drugs against...
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Senior Principal Scientist
3 weeks ago
Cambridge, Massachusetts, United States Novartis Group Companies Full timeJob SummaryAs a Senior Principal Scientist in the Translational Medicine Drug Disposition Bioanalytical group at Novartis Group Companies, you will have the opportunity to make a significant impact in the development of novel modality biologics. This vital leadership role requires a collaborative nature, a commitment to teamwork, and a relentless focus on...
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Cambridge, Massachusetts, United States Bristol-Myers Squibb Full timeTransforming Patients' Lives through ScienceBristol-Myers Squibb is a leading biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that transform patients' lives. We are seeking a highly skilled and experienced Senior Principal Scientist/Associate Director Neurology to join our Translational Medicine team.About...
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Lead Scientist
4 weeks ago
Cambridge, Massachusetts, United States Novartis Farmacéutica Full timePosition Overview:We are looking for a dedicated and skilled Lead Scientist in the field of Oncology Pharmacokinetics to join our team at Novartis Farmacéutica. This role is essential in advancing our mission to develop innovative therapies that improve patient outcomes.Role Summary:The Lead Scientist will be a key member of the PK Sciences team,...
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Scientist in Preclinical Pharmacology
4 weeks ago
Cambridge, Massachusetts, United States Vaxess Technologies Full timeLocation: Cambridge, MAVaxess Technologies is at the forefront of developing advanced vaccines and therapies utilizing its proprietary MIMIXTM Microneedle Array Patch technology. This innovative approach allows for self-administration of vaccines and therapeutics to the skin, potentially enhancing shelf-stability, tolerability, and overall efficacy. Our...
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In Vivo Pharmacology Scientist
4 weeks ago
Cambridge, Massachusetts, United States Vaxess Technologies Full timeLocation: Cambridge, MAVaxess Technologies is at the forefront of developing innovative vaccines and therapies utilizing its proprietary MIMIXTM Microneedle Array Patch technology. This advanced technology facilitates self-administration of vaccines and therapeutics through the skin, potentially enhancing shelf-stability, tolerability, and overall efficacy....
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Lead Scientist in Oncology Pharmacokinetics
1 month ago
Cambridge, Massachusetts, United States Novartis Farmacutica Full timeJob OverviewWe are looking for a dedicated and skilled Lead Scientist in Oncology Pharmacokinetics to join our PK Sciences team at Novartis. This role is essential in shaping and executing DMPK and clinical pharmacology strategies that drive the development of groundbreaking therapies from initial discovery stages through to advanced clinical trials.Key...