Principal Scientist

6 days ago


Cambridge, Massachusetts, United States Novartis Group Companies Full time
Job Summary

We are seeking an experienced Senior Principal Scientist or Principal Scientist to join our Oncology Research and Development team at Novartis Group Companies. The successful candidate will be responsible for developing and implementing pharmacokinetics and clinical pharmacology strategies to support the development of innovative medicines.

Key Responsibilities
  • Project Team Representation: Represent the Pharmacokinetics Sciences function in project teams, interactions with stakeholders within the organization, and interactions with regulatory agencies.
  • PK Strategy Development: Develop the pharmacokinetic strategy for lead optimization and oversee the execution of nonclinical studies to identify compounds with favorable pharmacokinetic properties.
  • PK/PD Evaluation: Work with teams to elucidate the understanding of pharmacokinetic/pharmacodynamic relationships and develop dosing strategies and predictions.
  • Clinical Pharmacology Strategies: Develop and execute clinical pharmacology strategies, including input into nonclinical and clinical study design, and analyzing pharmacokinetic and pharmacodynamic data, to support compound development from discovery through late development.
  • Study Protocol Development: Develop and execute PK, dosimetry (radiopharmaceuticals), PK/PD, and modeling and simulation components of study protocols, reports, project summaries, and development plans.
Requirements
  • Education: Ph.D. or Pharm.D. with relevant experience in clinical pharmacology, drug metabolism, and pharmacokinetics or a related background.
  • Experience: A minimum of 2 years of experience in drug discovery and/or development in a relevant environment (academia, CRO, biotech, or Pharma). For Senior Principal Scientist level, 4+ years of experience, including 2+ years of experience in a lead role overseeing ADME/DMPK project strategy, either in discovery or clinical development.
  • Skills: Extensive and in-depth knowledge of pharmacokinetics, including drug metabolism and PK/PD evaluation, experience in working in project teams (preferably global), and sound awareness of recent developments in drug development and regulatory sciences.
  • Communication: Strong oral and written communication skills.
Desirable Requirements
  • Hands-on Experience: Hands-on project experience with drug conjugates and/or radiopharmaceuticals is a plus.

  • Principal Scientist

    2 months ago


    Cambridge, Massachusetts, United States Nuvalent, Inc Full time

    Reporting to the VP, Medicinal Chemistry, the Principal Scientist, Medicinal Chemistry will have strong technical and problem-solving skills in organic and medicinal chemistry skills.The scientist in this position will work with the Nuvalent team, including the scientific founder, and will be responsible for leading medicinal chemistry efforts on at least...


  • Cambridge, Massachusetts, United States Proclinical Full time

    Principal Associate Scientist for Analytical Development - Contract - Cambridge, MA Proclinical is actively seeking a Principal Associate Scientist. This is a temporary contract position based in Cambridge, Massachusetts, MA. Primary Responsibilities:This role is primarily focused on the initial characterization testing, annual re-qualification, and trending...


  • Cambridge, Massachusetts, United States DeepRec Full time

    Job Title: Principal NLP Machine Learning ScientistAbout the Role:We are seeking a highly skilled Principal Machine Learning Scientist to join our team at DeepRec. As a key member of our team, you will be responsible for developing and training large-scale language models, fine-tuning models with feedback, and integrating multimodal scientific data.Key...

  • Principal Scientist

    4 days ago


    Cambridge, Massachusetts, United States Bristol-Myers Squibb Full time

    About the RoleBristol-Myers Squibb is seeking a highly skilled Principal Scientist to join our Computational Design and Predictive Modeling team in Cambridge, MA. As a key member of our team, you will play a critical role in developing novel bioinformatics and machine learning solutions to analyze and characterize antibody repertoire sequencing data.Key...


  • Cambridge, Massachusetts, United States Newton Colmore Full time

    About the RoleWe are seeking a highly experienced Senior DMPK and ADME Expert to join our research team at Newton Colmore. As a Principal Scientist in Drug Development, you will play a key role in designing and implementing in vivo PK studies, providing updates and results to research teams, and presenting strategies at governance interactions.Key...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Job SummaryAs a Senior Principal Scientist in the Translational Medicine Drug Disposition Bioanalytical group at Novartis Group Companies, you will have the opportunity to make a significant impact in the development of novel modality biologics. This vital leadership role requires a collaborative nature, a commitment to teamwork, and a relentless focus on...


  • Cambridge, Massachusetts, United States Amgen Full time

    HOW MIGHT YOU DEFY IMAGINATION?If you feel like you're part of something bigger, it's because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world's leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better...


  • Cambridge, Massachusetts, United States Amgen Full time

    HOW MIGHT YOU DEFY IMAGINATION?If you feel like you're part of something bigger, it's because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world's leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Position OverviewJoin our team as a Senior Principal Scientist within the Translational Medicine Drug Disposition Bioanalytical division. This role offers a unique opportunity to enhance your leadership capabilities while contributing to our mission of improving patient outcomes. We seek individuals who thrive in collaborative environments and are dedicated...


  • Cambridge, Massachusetts, United States Flagship Ventures Full time

    Job SummaryWe are seeking an experienced and highly motivated Principal Scientist with a proven track record of early discovery and characterization of novel biologics to join our team at Flagship Ventures.Key ResponsibilitiesConduct impactful research and experiments for biologics discovery and advancement of our platform.Influence the direction of...


  • Cambridge, Massachusetts, United States Sarepta Therapeutics Full time

    About the RoleWe are seeking a highly skilled and experienced Principal Scientist to join our RNA Research group at Sarepta Therapeutics. As a key member of our dynamic and fast-paced chemistry team, you will be responsible for designing and conducting novel oligonucleotide conjugates synthesis, purification, and characterization. You will also apply...


  • Cambridge, Massachusetts, United States Amgen Full time

    HOW MIGHT YOU DEFY IMAGINATION?If you feel like you're part of something bigger, it's because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world's leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better...


  • Cambridge, Massachusetts, United States The University of Texas MD Anderson Cancer Center Full time

    Job Title: Principal/Senior/Scientist, Biomolecular AnalysisJob Summary:We are seeking a highly skilled Senior Scientist, Biomolecular Analysis Specialist to join our team at The University of Texas MD Anderson Cancer Center. As a key member of our research team, you will be responsible for driving the biomolecular characterization to support platform...


  • Cambridge, Massachusetts, United States Akebia Therapeutics Full time

    About the RoleWe are seeking a highly skilled and experienced Principal Scientist, Drug Product Development to join our CMC Technical Operations team at Akebia Therapeutics. As a key member of our team, you will be responsible for providing strategic and technical leadership in the development and execution of drug product strategies for our clinical and...


  • Cambridge, Massachusetts, United States Flagship Ventures Full time

    About Flagship VenturesFlagship Ventures is a pioneering biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability.Job SummaryWe are seeking a highly motivated and experienced Principal Scientist, Medicinal Chemistry to join our team at Quotient Therapeutics,...


  • Cambridge, Massachusetts, United States Amgen Full time

    HOW MIGHT YOU DEFY IMAGINATION?If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products...

  • Principal Scientist

    7 days ago


    Cambridge, Massachusetts, United States Generation Bio Full time

    About the RoleGeneration Bio is a pioneering biotechnology company innovating non-viral genetic medicines to provide durable and redosable treatments for hundreds of millions of patients living with rare and prevalent diseases.We are seeking an experienced and highly motivated molecular biologist with a broad mechanistic understanding of mammalian cellular...


  • Cambridge, Massachusetts, United States Akebia Therapeutics Full time

    About the RoleWe are seeking a highly skilled and experienced Principal Scientist, Drug Product Development to join our CMC Technical Operations team at Akebia Therapeutics. As a key member of our team, you will be responsible for providing strategic and technical leadership in the development and execution of drug product strategies for our clinical and...


  • Cambridge, Massachusetts, United States Novartis Farmacéutica Full time

    About the RoleIn this vital leadership position, you will use your leadership skills, scientific acumen, operational excellence, and regulated bioanalysis experience to lead a team of scientists in method development, validation, and sample analysis focusing on our novel modality biologics portfolio.Your Key Responsibilities Will Include:Overseeing the...


  • Cambridge, Massachusetts, United States Novartis Group Companies Full time

    Position OverviewLocation: Onsite. Internal Title: Principal Scientist I/II About the Role: The Oncology Translational Research (OTR) team at Novartis is in search of a driven professional to take on the role of lab head, focusing on the exploration of mechanisms behind the effectiveness and resistance to innovative cancer treatments. Collaborating closely...