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Senior Scientist, Discovery Program Lead
2 months ago
CAMP4 Therapeutics is seeking a highly skilled and experienced scientist to lead our Discovery team in driving cutting-edge projects from target selection through development candidate selection. As a Principal Scientist, Discovery, you will be responsible for driving innovative science to develop antisense oligonucleotide drugs against regulatory RNAs, a novel class of targets to treat a range of both central nervous system (CNS) and metabolic diseases.
Key Responsibilities- Serve as a thought leader/internal expert in oligonucleotide drug discovery, primarily in CNS, but also metabolic disease spaces.
- Lead early-stage drug discovery projects from target selection through development candidate selection in a collaborative and matrixed environment.
- Lead from the bench with hands-on execution of in vitro and in vivo proof-of-concept studies and evaluation of pharmacology of antisense oligonucleotides targeting regulatory RNAs.
- Actively partner across all functions (platform, data science, chemistry, etc) and represent projects to R&D and leadership teams.
- Author internal research reports and contribute to regulatory documents (IB, IND, etc) in support of development programs.
- Communicate CAMP4's science to external community through presentation at conferences and peer-reviewed publications.
- Technical oversight and mentoring of scientists in both direct management and matrixed environment to facilitate career growth and personal development.
- Ph.D. in Biology, neuroscience, pharmacology, or related field with + >5 years of relevant industry experience.
- Fundamental understanding of oligonucleotide drug development, including screening strategies and lead optimization, target validation, and pharmacological principles.
- Experience leading cross-functional oligonucleotide drug discovery programs, preferably in both CNS and non-CNS disease areas.
- Hands-on experience with a wide array of cell culture, primary rodent and iPSC-derived culture systems to assess pharmacology, phenotypic characterization, assay development, and efficacy.
- Experience (hands on, or through management of external studies) with mouse efficacy / pharmacology models, including principles of in vivo study design to assess efficacy and pharmacology.
- Broad expertise across molecular, cellular, and biochemical techniques, including analyses of RNA and protein, microscopy, electrophysiology (e.g., MEA), tissue analyses, etc.
- Knowledge of transcriptional regulation, epigenetics or signal transduction is desirable.
- Experience managing and mentoring junior scientists, including technical oversight and personal growth.
- Experience operating in a matrixed environment and ability to influence activities more broadly in discovery group beyond your primary project.
CAMP4 Therapeutics is developing disease-modifying treatments for a broad range of genetic diseases where amplifying healthy protein may offer therapeutic benefits. Our approach amplifies mRNA by harnessing a fundamental mechanism of how genes are controlled. To amplify mRNA, our therapeutic ASO drug candidates target regulatory RNAs (regRNAs), which act locally on transcription factors and are the master regulators of gene expression. CAMP4's proprietary RAP Platform enables the mapping of regRNAs and design of optimal chemistry to generate potent therapeutic candidates to address hundreds of genetic diseases across multiple tissues.
