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Scientist in Preclinical Pharmacology

2 months ago

Cambridge, Massachusetts, United States Vaxess Technologies Full time

Location: Cambridge, MA

Vaxess Technologies is at the forefront of developing advanced vaccines and therapies utilizing its proprietary MIMIXTM Microneedle Array Patch technology. This innovative approach allows for self-administration of vaccines and therapeutics to the skin, potentially enhancing shelf-stability, tolerability, and overall efficacy. Our mission is to create products that are accessible to patients globally.

Our research and development efforts at Vaxess are interdisciplinary, merging biology, chemistry, immunology, materials science, and engineering to tackle significant unmet medical needs in the fields of vaccines and therapeutics. We are looking for a skilled, collaborative, and highly motivated professional with a strong background in animal models, pharmacology, and immunology to join our dedicated team of scientists and engineers. This role presents a unique opportunity to contribute to a thriving clinical-stage biotech company that is pioneering innovative technology for the global market.

Key Responsibilities

  • Lead the design of studies focused on immunogenicity and pharmacokinetics, collaborating with key internal and external stakeholders throughout the process. Assist in the design of IND-enabling safety and efficacy studies.
  • Oversee direct reports within the preclinical team, coordinating personnel support and essential resources to ensure successful study outcomes. Provide hands-on support and cross-training as necessary.
  • Manage external animal studies conducted at Contract Research Organizations (CROs) and ensure effective transfer of materials and protocols.
  • Collaborate with internal teams in research and early development, defining critical questions for platform animal model and device development.
  • Present findings in both internal and external meetings and lead the writing of scientific reports.
  • Develop or enhance organizational tools to compile in vivo study endpoints for visibility across the team.
  • Ensure compliance with IACUC regulations and facilitate training and credentialing for new team members.

Qualifications

  • PhD with 1-3 years of relevant experience or BS/MS with a minimum of 5 years of experience in pharmacology, biology, or a related field within the biotech or pharmaceutical industry.
  • Proven experience in the design and analysis of pharmacokinetic and pharmacodynamic (PK/PD) studies is essential.
  • Hands-on experience with various rodent models, including mice and rats, along with experience managing or conducting large animal studies in swine or non-human primates.
  • Ability to interpret clinical signs and basic animal health screening data proficiently.
  • Experience in training junior staff on various administration and blood sampling techniques.
  • Familiarity with IACUC review and approval processes.
  • Exceptional verbal and written communication skills.
  • Dedicated to working collaboratively within an interdisciplinary, cross-functional team.

Vaxess, a venture-backed clinical-stage life sciences company, is committed to building a team of exceptional individuals to rapidly advance products on the MIMIXTM platform. We foster a collaborative environment and thrive in a dynamic, engaging workplace.