Senior Scientist, Molecular Bioanalytics Expert
4 days ago
Editas Medicine is seeking a highly skilled Senior Scientist to join our DMPK, Nonclinical Safety and Translational Sciences (DSTS) team. As a key member of our team, you will be responsible for supporting ADME, biodistribution, PK/PD and bioanalytical activities.
Key Responsibilities- Develop and Execute Molecular Bioanalytical Assays: Establish and execute stage-appropriate molecular bioanalytical assays in support of DMPK, tox, biodistribution and PK/PD studies.
- Lead Bioanalytical Method Development: Develop and execute PCR-based methods, sample analysis, data generation, and report writing for preclinical and clinical samples.
- Design and Execute In Vitro and In Vivo Studies: Responsible for the design and execution of in vitro and in vivo studies to address ADME questions aligned with our overall scientific strategy.
- Ensure Data Quality and Integrity: Ensure that the data obtained is of the highest quality, and stage appropriate.
- Write Bioanalytical Assay Protocols and Reports: Write bioanalytical assay protocols and reports that are suitable for inclusion in registration dossiers.
- Contribute to Scientific Publications: Contribute effectively to patents, reports, and publications of scientific findings.
- Lead and Mentor Team Members: Model behaviors of a strong leader and mentor to staff members as appropriate.
- Establish Partnerships and Collaborations: Establish strong partnerships across sites and across functions; Work cross-functionally within the R&D organization.
- Ensure Compliance and Data Integrity: Ensure compliance with electronic notebooks (ELN), high data integrity and company policies.
- PhD in Pharmaceutics, Medicinal Chemistry, Analytical Chemistry, DMPK or Relevant Discipline: The ideal candidate will possess a PhD in pharmaceutics, medicinal chemistry, analytical chemistry, DMPK or a relevant discipline, with a minimum of 3 years of drug discovery experience; Bachelor's/Master's degrees with extensive and relevant industry experience will also be considered.
- Extensive Knowledge and Experience in Quantitative Bioanalysis: Extensive knowledge and experience in conducting quantitative bioanalysis using molecular bioanalytical techniques such as qPCR, ddPCR to support discovery and development projects.
- Demonstrated Knowledge and Experience in Bioanalytical Methods: Demonstrated knowledge and experience in establishing bioanalytical methods, ADME, PK/PD for a variety of therapeutic modalities, ideally in preclinical environment.
- Leadership and Team Management Experience: Experience in leading and developing strong, technical, delivery-focused teams is a plus.
- Gene Editing and Gene Delivery Technologies: Experience with gene editing or gene delivery technologies and lipid nanoparticle delivery is highly desired.
- Excellent Communication and Collaboration Skills: Excellent communication skills and proven ability to collaborate with interdisciplinary teams, along with exceptional scientific thinking and problem-solving skills.
- Ability to Multi-Task and Meet Research and Development Goals: Ability to multi-task to meet research and development goals in a fast-paced environment.
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