Lead Scientist, Molecular Bioanalytics
1 week ago
At Editas Medicine, our mission is to deliver groundbreaking therapies to individuals facing serious health challenges. We are committed to scientific excellence, leveraging the transformative capabilities of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing technologies.
We prioritize our workforce, fostering an environment where every team member feels appreciated and included. Our commitment to diversity, equity, and inclusivity is integral to our organizational culture.
Together, we are paving the way for a healthier, more equitable future.
Position Summary
Editas Medicine is in search of a dedicated bioanalytical scientist to enhance our DMPK, Nonclinical Safety, and Translational Sciences (DSTS) team. This role will report to the Senior Director of DMPK and Bioanalytical Sciences, focusing on supporting ADME, biodistribution, pharmacokinetics/pharmacodynamics (PK/PD), and bioanalytical initiatives.
The successful candidate will develop and implement molecular bioanalytical assays tailored to support DMPK, toxicity, biodistribution, and PK/PD studies. We seek an individual with robust technical expertise in PCR methodologies (ddPCR and/or TaqMan PCR), a comprehensive understanding of drug discovery and development processes, and the ability to collaborate effectively within a matrix team environment. The ideal candidate will demonstrate independent thinking, a positive team-oriented attitude, and the capacity to excel in a dynamic setting. Experience in gene therapy and lipid nanoparticle-based (LNP) delivery systems or nucleic acid therapeutics is advantageous.
Key Responsibilities:
- Develop and implement routine workflows for method development utilizing molecular bioanalytical assays (qPCR, ddPCR) to facilitate quantitative bioanalysis and apply innovative strategies to resolve complex challenges in advancing our pipeline.
- Conduct PCR-based methodologies, sample analysis, data generation, and documentation for both preclinical and clinical samples.
- Execute nucleic acid extraction (DNA/RNA) and quantification from a variety of animal tissues.
- Design and carry out in vitro and in vivo studies to address ADME inquiries aligned with our overarching scientific objectives.
- Implement bioanalytical assay development strategies to characterize ADME, pharmacokinetics, and biodistribution properties of drug products while addressing critical scientific inquiries.
- Ensure the integrity and quality of the data obtained, maintaining appropriateness for each stage of development.
- Draft bioanalytical assay protocols and reports suitable for inclusion in regulatory submissions.
- Contribute to patents, reports, and publications detailing scientific findings.
- Exemplify leadership and mentorship qualities to team members as necessary.
- Establish strong collaborations across various sites and functions; work cross-functionally within the R&D organization.
- Ensure adherence to electronic notebook (ELN) protocols, high data integrity, and company policies.
Qualifications:
Essential Qualifications:
The ideal candidate will possess:
- A PhD in pharmaceutics, medicinal chemistry, analytical chemistry, DMPK, or a related field, with a minimum of 3 years of experience in drug discovery; candidates with Bachelor's or Master's degrees and extensive relevant industry experience will also be considered.
- In-depth knowledge and experience in conducting quantitative bioanalysis using molecular bioanalytical techniques such as qPCR and ddPCR to support discovery and development initiatives.
- Proven expertise in establishing bioanalytical methods, ADME, and PK/PD across various therapeutic modalities, preferably in a preclinical context.
- Experience in leading and developing high-performing, technically proficient teams is a plus.
- Familiarity with gene editing or gene delivery technologies and lipid nanoparticle delivery is highly desirable.
- Exceptional communication skills and a demonstrated ability to collaborate with interdisciplinary teams, along with strong scientific reasoning and problem-solving capabilities.
- Ability to manage multiple tasks effectively to achieve research and development objectives in a fast-paced environment.
Benefits Overview:
Editas offers a comprehensive benefits package to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, a 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.
If you are a results-oriented and collaborative professional passionate about advancing transformative therapies, we encourage you to consider this opportunity. Contribute to Editas Medicine's mission of redefining healthcare through innovative genetic technologies.
Fostering Belonging. Fueling Innovation. Transforming Lives.
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