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Research Scientist

2 months ago

Cambridge, Massachusetts, United States Brigham & Women's Hospital(BWH) Full time
Job Summary

We are seeking a highly skilled Research Scientist to join our team at Brigham & Women's Hospital (BWH). As a key member of our bioanalytics team, you will be responsible for developing and validating bioanalytical methods for the analysis of small molecules, peptides, and proteins from preclinical and clinical samples.

Key Responsibilities
  • Develop and validate bioanalytical methods for HPLC, LCMS, ELISA, qPCR, and ICP-MS in complex matrices.
  • Design automated liquid handling programs for bioanalytical sample preparation, including protein precipitation, solid phase extraction (SPE), and supported liquid extraction (SLE).
  • Validate bioanalytical methods and evaluate the validation results against internal and FDA/ICH guidelines.
  • Prepare pre-clinical LCMS and GCMS samples with high precision and quality.
  • Operate LCMS, ELISA, PCR, GCMS, and ICP-MS equipment to analyze pre-clinical samples provided by formulation teams.
  • Troubleshoot and repair analytical instrumentation, and/or coordinate onsite repair from OEM service provider.
  • Train lower level staff, students, and scientists on bioanalytical techniques and help various programs design their experiments for successful analytical outcomes.
  • Assist in evaluating new capital assets and equipment for bioanalytics team.
  • Write and prepare standard operating procedures.
  • Support lead analytical chemist with requests, as needed.
  • Manage sample tracking in LIMS.
  • Document daily tasks and upload files to ELN.
  • Help enforce EH&S guidelines amongst team.
Qualifications
  • Ph.D. in chemistry (analytical or organic), or related field.
  • Demonstrated track-record of successful analytical chemistry research or experience in a research environment.
  • Track record of successful project management, ability to work independently and as part of a team, strong time management skills, and ability to self-problem solve.
  • Strong background in organic chemistry and biochemistry.
  • Bioanalytical assay development (HPLC, LCMS, immunological assays).
  • Chromatography (HPLC, LC, CE).
  • Mass spectrometry (LCMS, LC-MS/MS, LC-HRMS, GC-MS).
  • ELISA and AlphaLISA.
  • Electrophoresis.
  • PCR and qPCR.
Preferred Qualifications
  • Strong publication history in peer-reviewed journals.
  • Experience with photochemical analysis (UV-vis, fluorescence, FTIR).
  • Metal characterization (ICP-MS).
  • Experience with DSC, TGA, and Rheometry.
  • Familiarity with Karl Fischer analysis.
  • Knowledge of antibody, protein, and peptide purification from biological matrices.
  • Familiarization with chemstation, OpenLab, Masshunter, and Analyst is a plus, and prior experience operating Agilent instrumentation is preferred.
  • Expertise synthesizing small molecules and/or peptides.
What We Offer

We offer a dynamic and collaborative work environment, with opportunities for professional growth and development. Our team is committed to excellence and innovation, and we are seeking a highly motivated and skilled individual to join our team.

We are an equal opportunity employer and welcome applications from diverse candidates. We are committed to creating an inclusive and respectful work environment, and we encourage applications from candidates who share our values.