Lead Scientist, hiPSC Neuroscience Platform

2 weeks ago

Pasadena, California, United States AcuraStem Inc. Full time

Company Overview: AcuraStem Inc. is a pioneering organization in the preclinical phase, dedicated to addressing neurodegenerative disorders. Our focus lies in developing innovative therapeutic strategies for conditions such as ALS and FTD through the utilization of patient-derived stem cell models. We have established the iNeuroRx platform, leveraging human iPSC-derived cells to replicate neuromuscular and neurodegenerative conditions.

Position Summary: The Principal Scientist will oversee and enhance AcuraStem's existing platform technology, employing human iPSC-derived cell types to model neurodegenerative diseases and replicate disease characteristics. This platform will facilitate target discovery, validation, lead selection, and biomarker assessment. We are seeking candidates with extensive expertise in iPSC neurodegenerative disease models, high-content imaging, and assay development. The successful applicant will manage external partnerships and collaborate with internal teams to achieve early discovery research objectives. We are looking for a dedicated individual who is determined and innovative in developing new technologies and executing plans that yield high-quality scientific outcomes. This role is crucial in aligning the strategic vision of the platform team with the broader business goals, fostering innovation in the creation and commercialization of advanced, cost-effective assays. The Principal Scientist will serve as a technical and business mentor, leader, and coach for the platform team.

Key Responsibilities:
  • Innovate and implement all-human platforms to facilitate drug discovery and early-stage development.
  • Formulate and guide research strategies and activities to achieve program goals; provide leadership on projects, establish timelines, and develop contingency plans.
  • Utilize analytical methodologies, including experimental design and statistical process control, to identify and resolve assay performance challenges. Conduct statistical evaluations and devise solutions to enhance assay performance by minimizing variability and refining assay designs.
  • Communicate findings to both internal and external stakeholders, including leadership teams, partner organizations, and at scientific conferences.
  • Contribute to the drafting, editing, and review of documentation for regulatory submissions (e.g., study reports, Investigational Brochures, INDs, etc.).
  • Engage in writing grant proposals and progress reports.
  • Collaborate across departments and disciplines, serving as a scientific authority.
  • Demonstrate a strong commitment to mentoring team members and fostering individual growth and career advancement.
Qualifications:
  • Ph.D. with specialization in various neuroscience fields, including ALS, FTD, Tauopathies, or oligonucleotide therapies.
  • A minimum of 4 years of relevant industry experience is essential for the Principal Scientist role.
  • Extensive experience with iPSC differentiation protocols to neurons, neurospheres, and organoids (experience with glial cells and muscle cells is advantageous).
  • In-depth knowledge of neurodegenerative disease models, particularly TDP-43 proteinopathies.
  • Experience with high-content imaging platforms.
  • Proven track record in managing project timelines and resources effectively.
  • Experience in a matrixed environment; prior experience in small companies or startups is preferred.
  • High motivation and a demonstrated history of success.
  • Ability to thrive in a dynamic environment as a collaborative team player with strong work ethics, excellent communication skills, and effective time management.
Employment Type:

This is a full-time, regular on-site position.

Compensation:

At AcuraStem, we are committed to fostering a diverse and equitable workplace. The salary range for this position is $138,000 – $195,000, with compensation influenced by various factors, including qualifications, skills, competencies, and experience. AcuraStem provides a competitive total rewards package, encompassing healthcare coverage, a 401k plan, and a wide array of additional benefits.

Benefits: AcuraStem is dedicated to investing in our employees, recognizing their crucial role in achieving our mission and success. We strive to create a balanced environment that allows for professional fulfillment while providing the time and resources necessary for a healthy and satisfying life.

  • Comprehensive Medical, Dental, and Vision coverage - AcuraStem covers 100% of qualifying employee medical premiums and those for their eligible dependents.
  • Insurance options including Employee Assistance Programs, Basic Life Insurance, Short/Long Term Disability, and more.

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