Lead Scientist, hiPSC Neuroscience Platform

1 week ago

Pasadena, California, United States AcuraStem Inc. Full time

About AcuraStem Inc.
AcuraStem is a pioneering company in the preclinical stage, dedicated to addressing neurodegenerative disorders. Our focus is on developing innovative therapeutic strategies for conditions such as ALS and FTD through the use of patient-derived stem cell models. We have established the iNeuroRx platform, which employs human iPSC-derived cells to replicate neuromuscular and neurodegenerative diseases.

Position Overview
The Principal Scientist will play a crucial role in managing and enhancing AcuraStem's platform technology, utilizing human iPSC-derived various CNS cell types to model neurodegenerative diseases and replicate disease characteristics. This platform will be instrumental in target discovery, validation, lead selection, and biomarker assessment. We are looking for candidates with extensive expertise in iPSC neurodegenerative disease models, high-content imaging, and assay development. The successful candidate will oversee external collaborations and collaborate with internal cross-functional teams to achieve early discovery research objectives. We seek a dedicated individual who is relentless in advancing novel technologies and executing plans that yield high-quality scientific outcomes. This role will align the strategic direction of the platform team with the broader business strategy, fostering innovation in the development and commercialization of new, high-performance, and cost-effective assays. The Principal Scientist will also serve as a technical and business mentor, leader, and coach for the platform team.

Key Responsibilities:
  • Design and implement innovative all-human platforms to facilitate drug discovery and early development.
  • Lead research strategy and activities to fulfill program goals; establish project leadership, timelines, and contingency plans.
  • Utilize analytical techniques, including experimental design and statistical process control, to troubleshoot assay performance issues. Conduct statistical analyses and devise solutions to enhance assay performance by minimizing variability and refining assay designs.
  • Communicate findings to internal and external stakeholders, including leadership teams, partner organizations, and scientific conferences.
  • Contribute to the preparation, editing, and review of documents for regulatory submissions (e.g., study reports, IBs, INDs).
  • Engage in writing grant proposals and progress reports.
  • Collaborate with various departments and disciplines, acting as a scientific authority.
  • Demonstrate a strong commitment to mentoring staff and fostering individual growth and career development.
Qualifications:
  • Ph.D. with expertise in multiple areas of neuroscience, including ALS, FTD, Tauopathies, or oligonucleotide therapy.
  • A minimum of 4 years of industry experience is required for the Principal Scientist level.
  • Extensive experience with iPSC differentiation protocols to neurons, neurospheres, and organoids (experience with glial cells and muscle cells is advantageous).
  • In-depth knowledge of neurodegenerative disease models, particularly in TDP-43 proteinopathies.
  • Experience with high-content imaging platforms.
  • Proven track record of managing project timelines and resources effectively.
  • Experience in a matrixed environment; prior experience in small companies or startups is preferred.
  • High motivation and a demonstrated record of accomplishments.
  • Ability to thrive in a dynamic environment as a team player with a strong work ethic, excellent communication skills, and effective time management.
Job Type

This is a full-time regular on-site position.

Compensation

At AcuraStem, we are committed to fostering a diverse and equitable workplace. The salary range for this role is $138,000 – $195,000, depending on various factors, including qualifications, skills, competencies, and experience. AcuraStem offers a competitive total rewards package that includes healthcare coverage, a 401k plan, and a comprehensive range of additional benefits.

AcuraStem is dedicated to investing in our employees, who are vital to our mission and success. We strive to create a balance that allows you to find fulfillment in your work while having the time and resources to lead a happy and healthy life.

  • Medical, Dental, and Vision coverage - AcuraStem pays 100% of qualifying employee medical premiums and those for their qualifying dependents.
  • Insurance options for Employee Assistance Programs, Basic Life Insurance, Short/Long Term Disability, and more.

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