Protein Engineering Scientist
2 weeks ago
Position: Scientist, Discovery Research
Department: Research and Development
Company: Capstan Therapeutics, Inc.
Capstan Therapeutics, Inc. is a pioneering biotechnology firm focused on enhancing in vivo cell reprogramming. Our innovative platform utilizes proprietary targeted lipid nanoparticles (tLNPs) designed to deliver therapeutic payloads, including mRNA and gene editing tools, to specific cell types within the body. This technology holds promise for developing groundbreaking therapies across various disease areas, such as autoimmune conditions, cancer, fibrosis, and genetic blood disorders.
The RoleWe are seeking a dedicated Scientist in Protein Engineering to contribute to the design and optimization of CAR T therapies, collaborating with both internal teams and external partners. The primary objective of this role is to enhance novel mRNA-based CAR T constructs for application in diverse therapeutic contexts.
Key Responsibilities:- Lead the identification of potential product candidates by creating and implementing detailed research strategies.
- Engage in all facets of antibody discovery and receptor engineering, including library design, screening, and binder identification to achieve program objectives.
- Develop CARs, multi-format antibody constructs, and other protein-based entities for cell-based and recombinant expression.
- Formulate molecular biology strategies for cloning relevant constructs and developing libraries.
- Create plasmids and lentivirus vectors tailored for specific applications.
- Employ advanced methodologies such as electroporation, viral delivery, and nanoparticle transfections to modify mammalian cells.
- Utilize flow cytometry and functional assays to rigorously characterize mammalian cells.
- Conduct precise mammalian cell culture practices with strict aseptic techniques.
- Maintain high laboratory standards, including thorough documentation in an online lab notebook, instrument validation, and adherence to safety protocols.
- Build collaborative relationships within a cross-functional team, contributing significantly to project teams focused on developing and standardizing cell-based assays across various initiatives.
- Effectively organize and communicate data through written and verbal channels, actively participating in project meetings.
- Ph.D. in a relevant scientific field (preferably Protein Engineering, Immunology, Cell Biology, or similar) with a minimum of 2 years of industry experience or equivalent.
- Experience in structure-based engineering of CARs, antibodies, or related proteins.
- Proficient in molecular biology techniques, including Gibson, Golden Gate, and library construction.
- Strong background in mammalian display and NGS methodologies for antibody discovery and CAR-T engineering is highly desirable.
- Prior experience in developing antibody therapeutics, particularly bispecific or ADC, is advantageous.
- Demonstrated success in producing lentivirus/retrovirus and engineering primary T cells for CAR or TCR production.
- Familiarity with non-viral gene transfer techniques for mammalian cell engineering is a plus.
- Experience in designing and executing assays to assess T cell functionality, including cytotoxicity, activation, proliferation, and cytokine production.
- Knowledge of plate-based assay development and proficiency in automated liquid handling systems is beneficial.
- Familiarity with scientific data analysis software such as GraphPad Prism, FlowJo, or CellEngine, and experience analyzing large datasets with R, Python, or similar tools is advantageous.
- Proven ability to conceive and execute research projects independently while contributing to team efforts.
- Strong organizational and time-management skills, capable of managing multiple projects with effective documentation practices.
- Excellent communication and interpersonal skills, demonstrating a strong team-oriented approach.
- Ability to adapt, respond, and maintain organization with keen attention to detail.
- Strong analytical and problem-solving capabilities.
- Ability to thrive in a fast-paced, dynamic work environment.
- Competitive salary range based on experience.
- Performance-based bonuses.
- Employee Stock Option Program.
- 401(k) plan with employer matching.
- Comprehensive medical, dental, and vision coverage.
- Short- and long-term disability insurance.
- Flexible Spending Account (FSA) options.
- Generous paid time off and company holidays.
- Employee Assistance Program.
- Onsite fully stocked kitchens.
Capstan Therapeutics is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
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