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Senior Biotechnology Scientist, Protein Production
2 months ago
We are a cutting-edge biotechnology company dedicated to harnessing the power of CRISPR gene editing to revolutionize genetic medicine. Our team of world-renowned scientists brings expertise and proprietary technology to drive innovation and make a significant impact on human health.
The JobWe are seeking a highly motivated and qualified Protein Scientist to join our dynamic Protein Sciences team. The ideal candidate will bring deep expertise in protein purification and play a key role in designing and generating biomolecules that underlie our CRISPR gene editing technology.
Key Responsibilities:- Exercise high-level technical discretion on protein production projects, including conception, material generation, purification, and delivery of high-quality protein.
- Develop, optimize, scale-up, and troubleshoot protein production workflows.
- Implement new technologies to optimize current workflows and expand platform capabilities.
- Manage biophysical characterization of protein materials.
- Bring expertise in developing biologics.
- Coordinate and communicate progress across project teams.
- Analysis and interpretation of experimental results and assisting in the preparation of scientific reports and presentations, in addition to maintaining a detailed scientific notebook.
- PhD with at least 3 years of industry experience OR Bachelor's/Master's degree in Biology, Biochemistry, or other related scientific discipline with 10+ years of industry experience.
- Strong expertise in protein purification methodologies (affinity chromatography, ion-exchange, hydrophobic interaction, and size-exclusion) including extensive experience in designing and troubleshooting protein purification schemes.
- Operation and maintenance of AKTA and/or BioRad NGC system.
- Deep expertise in bacterial expression – including expression optimization and process development from small scale purification to large scale protein production.
- Previous experience managing bioreactors or fermenters is desirable.
- Familiarity with mammalian or cell-free expression technology is a plus.
- Experience in molecular biology including gene design, vector construction, and DNA sequence analysis is required, preference for scar-less methods (Gibson, Golden Gate, recombineering).
- Candidate will ideally be comfortable using structural software (Pymol, Chimera) to guide protein design.
- Mastery of standard protein quality assessment techniques (SDS-PAGE, MALS, DLS, ELISA, BLI, enzyme-linked functional assays...).
- Special consideration for candidates with demonstrable experience in the preclinical development of biologics.
- Attention to detail with rigorous scientific thinking and clear communication supported by appropriate documentation.
- Creative mindset to tackle difficult problems and propose solutions, as well as prioritize tasks across multiple projects.
- Strong team player with a desire to contribute to innovative technologies and drive success in an early-stage company.
Joining our team means becoming part of a dynamic, innovative, and supportive environment where your work will directly contribute to groundbreaking advancements in CRISPR-based technologies. We value diversity, encourage professional growth, and provide competitive benefits and compensation.
