Lead Scientist, Molecular Bioanalytics

2 weeks ago

Cambridge Massachusetts, United States Editas Medicine Full time

About Editas Medicine:
At Editas, we are united by a shared mission to deliver transformative therapies to individuals facing serious health challenges.

This commitment drives our pursuit of scientific excellence, enabling us to leverage the potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing technologies.


We recognize that our employees are the foundation of our success, and we are dedicated to fostering an environment where everyone feels respected and included. Our aim is to weave belonging, inclusivity, diversity, and equity into every facet of our organization.

Together, we are paving the way for a healthier and more equitable future.

Position Overview:
Editas Medicine is on the lookout for a driven bioanalytical scientist to become a vital part of our DMPK, Nonclinical Safety, and Translational Sciences (DSTS) team.

In this capacity, you will report to the Senior Director of DMPK and Bioanalytical Sciences, taking charge of supporting ADME, biodistribution, PK/PD, and bioanalytical initiatives.


Your responsibilities will include the development and execution of stage-appropriate molecular bioanalytical assays to support DMPK, toxicity, biodistribution, and PK/PD studies.

The ideal candidate will possess robust technical expertise in PCR-based methodologies (ddPCR and/or TaqMan PCR), a comprehensive understanding of drug discovery and development processes, and the ability to collaborate effectively within a matrix team structure.

We seek an independent thinker with a positive, team-oriented attitude, capable of thriving in a dynamic environment. Experience in gene therapy and familiarity with lipid nanoparticle-based (LNP) delivery systems and/or nucleic acid therapeutics is advantageous.


Key Responsibilities:
As the Lead Scientist in Bioanalytics, your duties will encompass:

  • Establishing and executing routine workflows for method development utilizing molecular bioanalytical assays (qPCR, ddPCR) to facilitate quantitative bioanalysis and implement innovative solutions to complex challenges.
  • Developing and executing PCR-based methodologies, conducting sample analyses, generating data, and preparing reports for preclinical and clinical samples.
  • Overseeing nucleic acid extraction (DNA/RNA) and quantification from a diverse range of animal tissues.
  • Designing and executing in vitro and in vivo studies to address ADME inquiries aligned with our overarching scientific strategy.
  • Implementing bioanalytical assay development strategies to characterize ADME, PK, and biodistribution properties of drug products while addressing critical scientific questions.
  • Ensuring the highest quality of data obtained is stage-appropriate.
  • Drafting bioanalytical assay protocols and reports suitable for inclusion in regulatory submissions.
  • Contributing effectively to patents, reports, and publications of scientific findings.
  • Exemplifying leadership and mentorship qualities to team members as appropriate.
  • Building strong partnerships across various sites and functions; collaborating cross-functionally within the R&D organization.
  • Ensuring compliance with electronic notebooks (ELN), maintaining high data integrity and adherence to company policies.


Required Qualifications:
The ideal candidate will possess:

  • A PhD in pharmaceutics, medicinal chemistry, analytical chemistry, DMPK, or a related field, with a minimum of 3 years of experience in drug discovery; Bachelor's/Master's degrees with extensive relevant industry experience will also be considered.
  • In-depth knowledge and experience in conducting quantitative bioanalysis using molecular bioanalytical techniques such as qPCR and ddPCR to support discovery and development projects.
  • Proven expertise in establishing bioanalytical methods, ADME, and PK/PD for various therapeutic modalities, ideally in a preclinical setting.
  • Experience in leading and developing strong, technically proficient, delivery-focused teams is a plus.
  • Familiarity with gene editing or gene delivery technologies and lipid nanoparticle delivery is highly desirable.
  • Excellent communication skills and a proven ability to collaborate with interdisciplinary teams, along with exceptional scientific reasoning and problem-solving capabilities.
  • The ability to manage multiple tasks to achieve research and development objectives in a fast-paced environment.


Benefits Overview:
Editas offers a comprehensive range of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, a 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

If you are a results-oriented and collaborative professional passionate about advancing transformative therapies, we encourage you to consider this opportunity.

Fostering Belonging. Fueling Innovation. Transforming Lives.

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