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Senior Scientist, Molecular Bioanalytics
3 months ago
At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.
We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.
Together, we are leading the way towards a healthier and more equitable future.
Position Summary
Editas Medicine is seeking a highly motivated bioanalytical scientist to join our DMPK, Nonclinical Safety and Translational Sciences (DSTS) team. In this role, you would report to the Sr. Director of DMPK and Bioanalytical Sciences and be responsible for supporting ADME, biodistribution, PK/PD and bioanalytical activities.
This individual will be responsible for developing and executing stage-appropriate molecular bioanalytical assays in support of DMPK, tox, biodistribution and PK/PD studies. The ideal candidate will have strong technical skills in PCR-based methods (ddPCR and/or TaqMan PCR), a broad understanding of drug discovery and development, and ability to work collaboratively with key partners in a matrix team structure. The individual in this role should be an independent thinker, possess a positive and team-centered mindset, and an ability to thrive in a fast-paced environment. Prior experience in gene therapy and with lipid nanoparticle based (LNP) delivery systems and/or nucleic acid therapeutics is a plus
Key Responsibilities:
As the Sr. Scientist Bioanalytical, you will be responsible for:
- Establishing and executing on routine workflows for method development using techniques such as molecular bioanalytical assays (qPCR, ddPCR) to support quantitative bioanalysis and apply innovative solutions to solve complex problems to advance the pipeline.
- Develop and execute PCR-based methods, sample analysis, data generation, and report writing for preclinical and clinical samples.
- Develop nucleic acid extraction (DNA/RNA) and quantification from a broad-spectrum animal tissues.
- Responsible for the design and execution of in vitro and in vivo studies to address ADME questions aligned with our overall scientific strategy.
- Execute bioanalytical assay development strategies to characterize ADME, PK and biodistribution properties of the drug product and address key scientific questions.
- Ensure that the data obtained is of the highest quality, and stage appropriate.
- Write bioanalytical assay protocols and reports that are suitable for inclusion in registration dossiers.
- Contribute effectively to patents, reports, and publications of scientific findings.
- Model behaviors of a strong leader and mentor to staff members as appropriate.
- Establish strong partnerships across sites and across functions; Work cross-functionally within the R&D organization.
- Ensure compliance with electronic notebooks (ELN), high data integrity and company policies.
Requirements
Required Qualifications:
The ideal candidate will possess:
- PhD in pharmaceutics, medicinal chemistry, analytical chemistry, DMPK or a relevant discipline, with a minimum of 3 years of drug discovery experience; Bachelor’s/Master’s degrees with extensive and relevant industry experience will also be considered.
- Extensive knowledge and experience in conducting quantitative bioanalysis using molecular bioanalytical techniques such as qPCR, ddPCR to support discovery and development projects.
- Demonstrated knowledge and experience in establishing bioanalytical methods, ADME, PK/PD for a variety of therapeutic modalities, ideally in preclinical environment.
- Experience in leading and developing strong, technical, delivery-focused teams is a plus.
- Experience with gene editing or gene delivery technologies and lipid nanoparticle delivery is highly desired.
- Excellent communication skills and proven ability to collaborate with interdisciplinary teams, along with exceptional scientific thinking and problem-solving skills.
- Ability to multi-task to meet research and development goals in a fast-paced environment.
Benefits
Benefits Summary:
Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.
If you are a results-focused and collaborative professional with a passion for advancing transformative therapies, we invite you to apply. Join us at the forefront of genetic innovation and be a key contributor to Editas Medicine's mission of redefining healthcare through cutting-edge genetic technologies.
Fostering Belonging. Fueling Innovation. Transforming Lives.
