Principal Scientist

1 month ago


Cambridge, Massachusetts, United States Nuvalent, Inc Full time

Reporting to the VP, Medicinal Chemistry, the Principal Scientist, Medicinal Chemistry will have strong technical and problem-solving skills in organic and medicinal chemistry skills.The scientist in this position will work with the Nuvalent team, including the scientific founder, and will be responsible for leading medicinal chemistry efforts on at least one early-stage project operating under a virtual/CRO model.As a member of a small team, the Principal Scientist is expected to execute across all aspects of medicinal chemistry.Further, the scientist will be responsible for external CRO team management and interfacing with Nuvalent's internal biology, computational chemistry, and DMPK teams.The ideal candidate is well-versed and experienced in organic synthesis and medicinal chemistry; has experience managing chemistry outsourcing; and has exceptional written and oral communication skills, interpersonal skills, and critical thinking skills.Drive medicinal chemistry efforts and structure-based drug discovery on kinase projects: designing high quality small molecules to enable and progress projects, from hit identification to candidatePh. D. in organic chemistry with 7 years of hands-on Medicinal Chemistry experience in the (bio)pharmaceutical industrySound knowledge of related disciplines (DMPK, biology, tox, )



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