Associate Director of Drug Metabolism and Pharmacokinetics

22 hours ago


Cambridge, Massachusetts, United States Bicycle Therapeutics Full time
Job Description

The Associate Director of Drug Metabolism and Pharmacokinetics (DMPK) plays a pivotal role in the success of our drug development pipeline at Bicycle Therapeutics. Reporting to the Vice President of Quantitative Pharmacology, this individual will be responsible for representing DMPK, designing and executing non-clinical studies in support of multiple projects from target identification through to candidate selection and ultimately regulatory submission.

Key Responsibilities
  • Develop and implement DMPK strategies to support project progression.
  • Design and execute experiments, review, interpret, and present data to multifunctional project teams.
  • Collaborate with external CROs and internal project stakeholders to perform DMPK activities.
  • Work closely with in-vivo pharmacology, toxicology, and/or clinical pharmacology to design experiments to understand preclinical PK/PD relationships and enable human efficacious dose projection.
  • Track DMPK budgets for CROs and contribute to project spending forecasts.
Requirements
  • MSc/PhD in a relevant scientific discipline such as drug metabolism, pharmacology, or pharmaceutical sciences.
  • Experience working on DMPK drug discovery and/or development projects as a DMPK representative with a track record of problem-solving and successful delivery across drug discovery.
  • In-depth understanding of DMPK science with additional knowledge of related disciplines.
  • Excellent organization and communication skills, both written and oral, with the ability to influence.
  • Hands-on experience in in vitro-in vivo extrapolation (IVIVE), PK, PK/PD, and/or physiologically based pharmacokinetic (PBPK) modeling preferred.
  • Experience supporting radiopharmaceutical projects desirable.
  • Experience working on peptides or macrocycles would be an advantage.
  • Experience using Dotmatics would be an advantage.
What We Offer
  • A state-of-the-art campus environment with on-campus restaurant and Montessori nursery.
  • A flexible working environment.
  • Competitive rewards, including an annual company bonus.
  • Employee recognition schemes.
  • 28 days annual leave in addition to bank holidays, plus the option to buy up to 5 additional days annually.
  • Employer contribution to pension.
  • Life assurance cover 4x basic salary.
  • Private Medical Insurance, including optical and dental cover.
  • Enhanced parental leave policies.
  • Group income protection.
  • Employee assistance program.
  • Health Cash Plan.
  • Access to company-subsidized gym membership.
  • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
  • Cycle to work scheme.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, color, gender, sexual orientation, age, disability status, marital status, or veteran status.


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