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Research Scientist in Metabolic Genetics

2 months ago

Cambridge, Massachusetts, United States Broad Institute Full time

Position Overview

The Broad Institute of MIT and Harvard stands at the forefront of biomedical research, dedicated to unraveling the molecular underpinnings of significant human diseases. Our mission encompasses the development of innovative diagnostic and therapeutic strategies, alongside the open dissemination of discoveries, methodologies, and data to the global scientific community.

About the Laboratory

The Claussnitzer lab, part of the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, is seeking a postdoctoral associate to enhance our Variant-to-Function (V2F) team. This dynamic group focuses on identifying genetic variants and elucidating gene regulatory networks that influence susceptibility to type 2 diabetes and related metabolic disorders.

The successful candidate will be pivotal in translating genetic insights into a deeper understanding of the molecular and cellular mechanisms of metabolic diseases, as well as in identifying actionable therapeutic hypotheses. We are looking for an innovative, proactive, and resourceful individual with expertise in cellular metabolism to spearhead research initiatives aimed at understanding the impact of genetic variants on gene regulatory networks and cellular processes associated with prevalent metabolic disorders.

Key Responsibilities

  • Develop and implement functional genomics methodologies and high-throughput screening strategies to evaluate variant and gene effects in disease-relevant metabolic outcomes and high-dimensional profiling assays.
  • Independently design, plan, and execute projects and experiments while collaborating closely with a multidisciplinary team.
  • Document, compile, analyze, and interpret experimental findings.
  • Actively participate in lab and project meetings, preparing reports and presenting progress towards project objectives.
  • Mentor and supervise other lab members, contributing significantly to scientific publications, presentations, and funding proposals.

Required Qualifications

  • PhD in molecular biology, cellular biology, or a related field.
  • Self-motivated and innovative leader capable of working independently and collaboratively in a fast-paced, highly interactive environment.
  • Strong interpersonal skills with the ability to foster excellent working relationships.
  • Capacity to manage multiple tasks and adapt in a dynamic, multidisciplinary research setting.
  • Exceptional organizational and time-management skills, with meticulous lab notebook practices and attention to detail.
  • Excellent verbal and written communication, critical thinking, and analytical abilities.
  • Experience in mammalian cell culture, development of cell-based assays, cellular metabolism, and molecular biology is essential.
  • Familiarity with imaging techniques, genome editing, arrayed or pooled screening, single-cell ATAC and/or RNA sequencing, and analysis of extensive datasets is preferred.
  • Experience working with primary adipocyte cells and relevant cell models is advantageous.