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Boston Pharmacokinetics, Dynamics, Metabolism and Bioanalytics – Associate Principal Scientist, Project Representative
4 months ago
Job Description
Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our company's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our company's Research Labs Boston, you'll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.
The Pharmacokinetics, Dynamics, Metabolism and Bioanalytic (PDMB) group is seeking a dynamic, strategic thinking and collaborative Associate Principal Scientist to contribute to our company's protein therapeutic drug discovery and early clinical development efforts. This position will be based at our research labs in Boston, MA. The ideal candidate will lead PDMB efforts as a project-team representative and PK/PD subject matter expert, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our Research & Development Division. Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well. The successful candidate will be expected to represent PDMB on cross-functional protein therapeutic teams through generation and interpretation of PK and PK/PD data as well as through effective communication at both internal meetings and external conferences.
In this exciting position, your primary roles will include:
- Project-team representative and subject matter expert on protein therapeutic-based PDMB activities including generation and interpretation of pharmacokinetic and pharmacokinetic/ pharmacodynamic (PK/PD) relationships in support our Research & Development Division's Immunology and Oncology therapeutic areas
- Design, implementation and analysis of in vitro and in vivo studies to understand the impact of drug disposition on disease biology and pharmacological response (PK/PD)
- Characterization of in vitro and in vivo ADME and pharmacokinetic properties of protein therapeutics including monoclonal antibodies and engineered proteins
- Close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) aimed at building highly efficient strategies to identify and optimize drug candidates
Education Minimum Requirement:
- Ph.D (with 3+ years relevant experience), Master's (minimum of 6 years relevant experience), or Bachelor's (minimum of 12+ years of relevant experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field; Relevant experience to include a record of increasing responsibility and independence in a similar industrial/academic setting
Required Experience and Skills:
- Experience contributing to development, execution, and fostering of translational pharmacokinetic-pharmacodynamic/efficacy relationships and other useful quantitative pharmacology applications in a discovery setting for protein therapeutics
- Demonstrated project-team leadership contributing to development, execution, and fostering of translational pharmacokinetic/pharmacodynamic/efficacy relationships for protein therapeutics
- Technical ability to analyze, interpret and provide context around data describing the pharmacokinetic and pharmacodynamic properties of protein therapeutics (monoclonal antibodies and engineered proteins), including use of software such as Phoenix WinNonlin
- Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast-paced environment
Preferred Experience and Skills:
- Therapeutic area expertise in immunology is a plus
- Hands-on experience performing translational pharmacokinetic/pharmacodynamic/efficacy and physiologically-based pharmacokinetic (PBPK) software modeling (e.g., Phoenix WinNonlin, Berkeley Madonna, MATLAB).
- Ability to design and interpret novel, hypothesis-driven ADME and bioanalytical strategies (LC/MS and/or ligand-binding assays) to support the optimization of monoclonal antibodies, engineered proteins, peptides and/or targeted therapies
- Proven track record supporting immunology or oncology-based programs with experience spanning from early discovery through IND-enabling efforts
- Familiarity with engineering strategies to improve pharmacokinetic and pharmacodynamic properties of protein therapeutics
- Experience working within a research-driven pharmaceutical company
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
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Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.
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Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".
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Employee Status:
RegularRelocation:
DomesticVISA Sponsorship:
YesTravel Requirements:
10%Flexible Work Arrangements:
HybridShift:
Not IndicatedValid Driving License:
NoHazardous Material(s):
n/aJob Posting End Date:
05/31/2024*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Job Posting End Date:05/31/2024
A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID:R294605
