Scientist, In vivo pharmacology

1 month ago

Cambridge, United States Third Rock Ventures Full time

Scientist, In vivo pharmacology

A well-funded and highly innovative start up from Third Rock Ventures is emerging out of stealth with a syndicate of marquee investors and is seeking a talented Scientist to join the Biology-In vivo pharmacology team. The Scientist will serve as the in vivo pharmacology representative for discovery-stage pipeline program(s) focused on antibody-driven diseases. The role will work collaboratively with the Biology team lead(s) to contribute to lead characterization and development candidate selection. The Scientist will aid in the establishment and management of internal in vivo pharmacology capabilities. The ideal candidate is an expert lab-based biologist with a background in immunology and pharmacology, toxicology experience preferred.

Responsibilities:

  • Aid in establishing and managing internal in vivo pharmacology capabilities at a shared vivarium space, including animal handling
  • Serve as functional team lead for pre-clinical pipeline program(s) and work collaboratively/partner with peer team leads to advance program(s) to IND
  • Design and manage in vivo biology functional experiments that support preclinical drug discovery including PK/PD analysis, mechanism of action studies, and disease modeling
  • Independently develop and execute quantitative assays for the analysis/characterization of ex vivo samples (ELISA, flow cytometry)
  • Manage some out-sourced CRO-based workflows

Required qualifications and experience:

  • Ph.D. in relevant scientific area, such as immunology, cell/molecular biology with 0-3 years in Biotech/Pharma industry or BA/BS in a relevant scientific area with 8+ years experience in Biotech/Pharma industry with a focus on in vivo pharmacology
  • Extensive experience in the design and execution of in vivo studies, including ex vivo analysis
  • Capability to work within a dynamic matrix environment, with strong contribution to project strategy and execution
  • Excellent communication, presentation, and inter-personal skills; superb organizational and problem-solving skills
  • Experience in the design of toxicology studies preferred
  • Contribution to the design and execution of IND-enabling in vivo studies preferred

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