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Principal Scientist II, Cell Therapies
2 months ago
Novartis Biologics Center (BRC) is seeking a highly skilled Principal Scientist II to join our Cell and Gene Therapy (CGT) group in San Diego, CA. As a key member of our team, you will have the opportunity to contribute to the development of innovative medicines for patients with devastating diseases.
Job Responsibilities- Lead and oversee next-generation CGT delivery improvement projects across multiple Novartis sites to enable pipeline and platform advances and novel therapeutic capabilities.
- Develop more potent, safer, and tolerable LVV and AAV vectors through innovative approaches, including improving tropism/targeting, reducing immune response, and optimizing vector components.
- Enable translation from in vitro/in vivo mouse and nonhuman primate POC studies to therapeutic disease programs for preclinical development.
- Initiate, lead, and contribute to interdisciplinary research programs in a highly collaborative and matrixed manner across internal groups and with external partners.
- Prepare reports, manuscripts, and protocols, adhering to good research practices and quality culture across NIBR. Present results at internal and external meetings and conferences.
- Bachelor's degree in cell and gene therapy, bioinformatics, molecular/cell biology, bioengineering, or related scientific field with 12 years of industry experience or Master's degree with 10 years of industry experience or PhD with 6 years of industry experience.
- Successful track-record in leading scientists and project team members with diverse backgrounds.
- Demonstrated expertise in LVV and AAV biology, virology, viral tropism engineering, transcriptional and post-transcriptional mechanisms, and analytical/process development for LVV/AAV production.
- Ability to work collaboratively across a dynamic and collaborative scientific and development environment.
- Genetic/epigenomic/transcriptomic profiling technologies, genome engineering (e.g., CRISPR), nonviral gene therapy, sh/miRNA biology, and analytical/process development for LVV/AAV production.
