Senior Research Scientist

4 weeks ago


San Diego, California, United States Poseida Therapeutics, Inc. Full time
Job Summary

Poseida Therapeutics, Inc. is seeking a highly motivated Research Scientist to join our Gene Therapy team in San Diego, CA. This position offers an exciting opportunity to discover and develop next-generation products using Poseida's best-in-class genome editing, gene insertion, and delivery technologies.

Key Responsibilities
  • Manage and execute in vivo and in vitro pharmacology work from discovery to drug candidate nomination, and IND-enabling activities working closely with formulations, analytical chemistry, molecular engineering, and translational teams.
  • Lead in vivo pharmacology activities in rodents and large animals for Poseida's in vivo genetic medicines team, comprising platform discovery, feasibility assessment, therapeutic proof-of-concept, and candidate nomination.
  • Plan and execute studies in rodents and large animals to characterize the in vivo pharmacology (PK/PD, biodistribution), toxicology, safety, and efficacy of Poseida's genetic medicines systems, including hands-on work designing/validating/implementing in vivo disease models.
Requirements
  • Ph.D. in a scientific discipline (e.g., molecular biology, cell biology, pharmacology, toxicology, immunology, or other relevant scientific field) with up to 2 years of relevant experience (an equivalent combination of education and experience may be considered).
  • Strong hands-on experience with complex drug formulations, such as nanoparticles and viral vectors, for in vivo gene therapy.
  • Demonstrated expertise in the biology and relevant animal models of at least one of the following classes of genetic diseases: urea cycle disorders, inborn errors of amino acid, carbohydrate, or lipid metabolism, organic acidemia, lysosomal storage disorders, or congenital hematologic diseases, strong preference for experience with Hemophilia.
What We Offer

Poseida Therapeutics, Inc. offers a competitive salary range of $108,000 - $120,000 for Research Scientist, $117,000 - $135,000 for Research Scientist II, and $130,000 - $150,000 for Senior Research Scientist, depending on experience and qualifications.


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