Principal Scientist, Translational Researcher
3 days ago
Bristol Myers Squibb is a leading pharmaceutical company dedicated to discovering and developing innovative treatments for patients with serious diseases. We are seeking a highly skilled Principal Scientist, Translational Research to join our team in San Diego, CA.
About the Role:
As a Principal Scientist, Translational Research, you will play a critical role in bridging laboratory research with clinical applications to advance novel radiopharmaceutical oncology therapies. You will work closely with cross-functional teams to translate scientific findings into actionable insights that inform clinical development strategies, identify biomarkers, and drive therapeutic innovations.
Key Responsibilities:
- Conduct immunohistochemistry (IHC) analysis to evaluate new targets identified by project teams and interpret and present IHC data to guide decision-making on target selection and validation.
- Utilize molecular and genetic tools to identify and validate anchor indications for novel therapies and analyze clinical and preclinical data to support the selection of lead indications.
- Provide strategic and operational translational leadership for project teams on specific targets and contribute to the development of translational research strategies aligned with therapeutic goals.
- Lead efforts to develop and execute strategies for generating data in relevant models, discover and validate biomarkers that predict patient response to therapies, and inform clinical trial designs.
- Develop and optimize preclinical in vivo models that mimic human cancer biology to evaluate drug efficacy, mechanism of action, and resistance mechanisms.
- Integrate biomarker findings into clinical development plans and regulatory submissions and investigate mechanisms of radiosensitivity and develop tools and models to predict response to radiotherapy and identify potential biomarkers.
- Investigate resistance mechanisms and propose strategies to overcome resistance through rational combinations and author/review study reports and regulatory documentation, scientific presentations, and publications.
Requirements:
- PhD in cancer biology, molecular/cell biology, pharmacology, or a related field and a deep understanding of cancer biology and experience working in oncology drug development.
- 5+ years of translational oncology experience in pharmaceutical/biotech R&D environments demonstrating successful accomplishments and progressive leadership and broadening responsibilities.
- Experience in working on targeted cancer therapy modalities such as RPTs, ADCs, PDCs is highly desirable.
What We Offer:
- Competitive salary and benefits package.
- Opportunities for professional growth and development.
- Collaborative and dynamic work environment.
- Access to cutting-edge technology and resources.
How to Apply:
If you are a motivated and experienced scientist looking to make a meaningful impact in the field of oncology, please submit your application, including your resume and a cover letter, to [insert contact information].
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