Research Scientist

2 days ago

San Diego, California, United States Poseida Therapeutics, Inc. Full time
Job Summary

Poseida Therapeutics, Inc. is seeking a highly motivated and experienced Research Scientist to join our Gene Therapy team in San Diego, CA. This is an exciting opportunity to contribute to the development of next-generation gene therapies and make a meaningful impact on patients' lives.

Key Responsibilities
  • Lead in vivo pharmacology activities in rodents and large animals to characterize the in vivo pharmacology (PK/PD, biodistribution), toxicology, safety, and efficacy of Poseida's genetic medicines systems.
  • Plan and execute studies in rodents and large animals to characterize the in vivo pharmacology (PK/PD, biodistribution), toxicology, safety, and efficacy of Poseida's genetic medicines systems.
  • Lead, design, execute bioanalytical assays relevant to the target disease(s).
  • Support internal Formulations and Analytical teams in the design and execution of experiments related to product analytical method development and bioassay development.
  • Work closely with Poseida's Formulations, Molecular Biology, and Chemistry teams in the design of next-generation genetic medicine platforms.
  • Stay abreast of new gene therapy platform and mechanistic results from Poseida and other companies.
  • Work effectively with internal and outsourced animal resources to manage disease model generation, colony maintenance, study execution and data analysis.
  • Work effectively with Poseida Project Management teams to set, maintain and manage program timelines and deliverables.
  • Author study design protocols, technical reports, and contribute to regulatory filings.
  • Analyze data and report to multidisciplinary groups.
  • Attend scientific meetings, critically evaluate data, and present scientific results.
  • Keep current on trends, new products and technologies in the gene therapy and gene editing fields.
  • Manage 1-4 Research Technicians, Research Associates, and/or Junior Scientists, as needed.
Requirements
  • Ph.D. in a scientific discipline (e.g., molecular biology, cell biology, pharmacology, toxicology, immunology, or other relevant scientific field).
  • Up to 2 years of relevant experience (an equivalent combination of education and experience may be considered) for Research Scientist I.
  • 2-5 years of relevant experience (an equivalent combination of education and experience may be considered) for Research Scientist II.
  • 5+ years of relevant industry experience (an equivalent combination of education and experience may be considered) for Senior Research Scientist.
  • Preference for demonstrated experience in transitioning one or more gene therapy program(s) from feasibility through disease proof-of-concept and/or candidate nomination.
  • Preference for background/certification in toxicology.
  • Strong hands-on experience with complex drug formulations, such as nanoparticles and viral vectors, for in vivo gene therapy.
  • Demonstrated expertise in the biology and relevant animal models of at least one of the following classes of genetic diseases: urea cycle disorders, inborn errors of amino acid, carbohydrate, or lipid metabolism, organic acidemia, lysosomal storage disorders, or congenital hematologic diseases, strong preference for experience with Hemophilia.
  • Experience with routine assays (qPCR and/or ddPCR, immune-staining (IHC/IFC), immunoassays (ELISA, MSD, Luminex) and Western blot) is highly desirable.
  • Familiarity with USDA, PHS, and AAALAC guidance on use of animals in research.
  • Must be highly motivated and capable of working in a multidisciplinary team environment with scientists and external collaborators.
  • Excellent written and verbal communications skills, and the ability to present and defend positions and approaches critical to program progression and success.
  • Critical-thinker and detail-focused manager with a desire to lead, inspire, and discover in the context of team-based cross-functional science.
Compensation

Research Scientist pay range (PhD with 0 to 2 years): $108,000 - $120,000

Research Scientist II pay range (PhD with 2 to 5 years): $117,000 - $135,000

Senior Research Scientist: (PhD with 5 plus years) $130,000 - $150,000

The final pay offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience with the industry, education, geographic location, etc.

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