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Chief of RNA Vaccine Research
2 months ago
Position Summary: MSK is on the lookout for a driven, innovative, and accomplished individual to lead its RNA Therapeutics Laboratory. This role is pivotal in establishing a research and development hub within the newly formed Center for Cancer Vaccines at MSK, a cornerstone of our immuno-oncology initiative.
Key Responsibilities:
- Direct the establishment of a comprehensive mRNA vaccine pipeline, focusing on platform optimization and GMP manufacturing for clinical applications.
- Supervise the design and development of RNA vaccines, including enhancements to optimize mRNA templates, structures, stability, and production techniques such as in vitro transcription, purification, and lipid nanoparticle encapsulation.
- Oversee quality control for RNA vaccines, developing and refining analytical assays to assess the quality and effectiveness of mRNA vaccines.
- Facilitate the transfer of these assays to the GMP-Therapeutics Core Facility and provide collaborative support for vaccine production.
- Guide and mentor technical staff while setting the strategic scientific direction of the laboratory based on emerging technologies and the needs of MSK's scientific community.
- Manage operational responsibilities, including advanced methods development, scientific consultation, and engagement with the broader scientific community to ensure a cutting-edge operation.
- Handle financial and human resource management, including recruitment, training, mentoring, and staff development.
- Collaborate closely with the MSK GMP-Therapeutics Core Facility to align the laboratory's objectives with institutional strategic goals, reporting to the Cancer Vaccine Center director and a faculty oversight committee.
- Ph.D. in immunology, cell biology, biochemistry, biophysics, or a related field.
- A minimum of 5 years of experience in either academic or commercial settings.
- Hands-on experience in experimental mRNA vaccine biology and the clinical development of GMP-grade mRNA vaccines; experience in new assay development is highly valued.
- Proficiency in mRNA customization, synthesis, and purification.
- Expertise in mRNA-LNP platforms, cGMP process flow, and analytical panel development; familiarity with IND applications is a plus.
- Strong interpersonal, written, and verbal communication skills.
- Experience in managing laboratory personnel and overseeing daily laboratory operations is essential.
- A highly skilled scientist with a keen focus, attention to detail, and sound decision-making abilities.
- A quick learner and adept problem-solver who can identify data anomalies and their sources effectively.
- Capable of multitasking, planning, and adjusting priorities to meet objectives in a dynamic environment.
- A motivated individual who can foster strong relationships within the lab and with internal and external collaborators.
- A mentor committed to the success of others, providing performance evaluations and constructive feedback.
- An effective communicator and presenter, skilled in tailoring messages for diverse audiences.
- A creative thinker and strategic planner who can innovate and adapt.
- Consistently delivers results, even in challenging circumstances.
- Schedule: Monday - Friday, 9 am - 5 pm.
- Reporting to: Director, Center of Cancer Vaccines.